Basic Information
ID: ALA4727995
Type: Binding
Description: Binding affinity to LEDGF/p75 binding pocket of integrase in HIV-1 NL432 infected in human MT4 cells assessed as allosteric inhibition of IN-LEDGF/p75 interaction by measuring inhibition of virus-induced cytopathicity measured after 4 days by MTT assay
Format: BAO_0000219
Organism: Human immunodeficiency virus 1
Strain: NL432
Cell type: MT4
Target: Unchecked(ALA612545)
Document: ALA4725334
Binding affinity to LEDGF/p75 binding pocket of integrase in HIV-1 NL432 infected in human MT4 cells assessed as allosteric inhibition of IN-LEDGF/p75 interaction by measuring inhibition of virus-induced cytopathicity measured after 4 days by MTT assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4727995
EC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 442.52 | 5.63 | 5.63 |
| 563.74 | 9.06 | 9.06 |
| 501.67 | 7.77 | 7.77 |
| 516.68 | 7.56 | 7.56 |
| 578.75 | 9.46 | 9.46 |
| 599.79 | 8.61 | 8.61 |
| 551.71 | 6.50 | 6.50 |
| 459.63 | 7.39 | 7.39 |
| 509.67 | 6.57 | 6.57 |
| 473.66 | 7.85 | 7.85 |
| 566.72 | 6.37 | 6.37 |
| 579.76 | 7.20 | 7.20 |
| 544.11 | 7.22 | 7.22 |
| 565.73 | 6.89 | 6.89 |
| 530.71 | 7.95 | 7.95 |
| 562.10 | 7.36 | 7.36 |
| 563.76 | 7.72 | 7.72 |
| 537.72 | 7.18 | 7.18 |
| 515.69 | 8.16 | 8.16 |
| 549.76 | 9.42 | 9.42 |
| 580.75 | 6.40 | 6.40 |