Basic Information
ID: ALA4728769
Type: Binding
Description: Negative allosteric modulation of human GluN1a/GluN2B receptor expressed in CHO cells assessed as inhibition of glutamate and glycine-induced calcium flux preincubated for 5 mins followed by glutamate and glycine addition and measured after 5 mins by calcium 5 dye based FLIPR assay
Organism: Homo sapiens
Cell type: CHO
Activity Charts
Bioactivity
Activity Types for Assay ALA4728769
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 376.34 | 2.69 | 2.69 |
| 342.42 | 2.00 | 2.00 |
| 378.40 | 2.63 | 2.63 |
| 414.38 | 2.66 | 2.66 |
| 384.38 | 2.57 | 2.57 |
| 378.40 | 2.63 | 2.63 |
| 396.39 | 2.71 | 2.71 |
| 408.36 | 2.60 | 2.60 |
| 368.46 | 2.57 | 2.57 |
| 390.37 | 2.65 | 2.65 |
| 330.41 | 1.86 | 1.86 |
| 378.35 | 2.51 | 2.51 |