Basic Information
ID: ALA4729275
Type: Binding
Description: Negative allosteric modulator activity at human PDE5A1 (535-860 residues) expressed in Escherichia coli BL21 assessed as Kcat/Km ratio for cGMP at 25 nM incubated for 15 mins using [3H]-cGMP as substrate by liquid scintillation counting method (Rvb = 0.6 +/- 0.04 /s/microM)
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4729275
Kcat/Km
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 363.42 | 3.33 | 3.33 |