Basic Information
ID: ALA4729810
Type: Binding
Description: Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrate preincubated for 1 hr followed by substrate addition
Format: BAO_0000019
Organism: Homo sapiens
Target: Protein disulfide-isomerase(ALA5422)
Document: ALA4725388
Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrate preincubated for 1 hr followed by substrate addition: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4729810
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 312.30 | 3.09 | 3.09 |
| 324.34 | 2.96 | 2.96 |
| 369.47 | 5.41 | 5.41 |
| 369.47 | 5.46 | 5.46 |
| 361.83 | 5.19 | 5.19 |
| 359.40 | 4.98 | 4.98 |
| 355.44 | 5.10 | 5.10 |
| 386.41 | 4.75 | 4.75 |
| 315.34 | 3.45 | 3.45 |
| 403.43 | 2.57 | 2.57 |
| 343.38 | 2.55 | 2.55 |
| 345.38 | 4.68 | 4.68 |
| 329.35 | 2.25 | 2.25 |
| 403.43 | 2.57 | 2.57 |
| 347.80 | 3.20 | 3.20 |
| 355.39 | 3.42 | 3.42 |
| 357.36 | 2.27 | 2.27 |
| 377.83 | 4.90 | 4.90 |
| 373.41 | 2.56 | 2.56 |
| 327.38 | 3.31 | 3.31 |
| 359.38 | 2.26 | 2.26 |
| 343.38 | 2.55 | 2.55 |
| 341.41 | 3.70 | 3.70 |
| 341.41 | 4.85 | 4.85 |
| 371.43 | 3.71 | 3.71 |
| 359.38 | 2.26 | 2.26 |
| 387.43 | 3.33 | 3.33 |
| 373.41 | 2.56 | 2.56 |
| 401.46 | 3.72 | 3.72 |
| 343.38 | 3.02 | 3.02 |
| 371.43 | 3.71 | 3.71 |
| 371.40 | 5.05 | 5.05 |
| 341.41 | 4.85 | 4.85 |
| 370.41 | 4.84 | 4.84 |
| 370.41 | 4.84 | 4.84 |
| 351.36 | 3.12 | 3.12 |
| 361.83 | 5.19 | 5.19 |
| 393.85 | 5.64 | 5.64 |
| 331.34 | 2.68 | 2.68 |
| 387.44 | 4.56 | 4.56 |
| 375.86 | 5.50 | 5.50 |
| 326.40 | 5.14 | 5.14 |
| 359.40 | 4.98 | 4.98 |
| 318.30 | 2.28 | 2.28 |
| 365.35 | 2.84 | 2.84 |
| 336.41 | 4.65 | 4.65 |
| 326.42 | 4.07 | 4.07 |
| 328.37 | 1.82 | 1.82 |
| 339.45 | 4.99 | 4.99 |
| 329.37 | 3.84 | 3.84 |
| 357.41 | 3.32 | 3.32 |
| 325.38 | 4.85 | 4.85 |
| 380.44 | 3.38 | 3.38 |
| 341.38 | 4.56 | 4.56 |
| 341.36 | 3.03 | 3.03 |
| 336.41 | 4.65 | 4.65 |
| 337.40 | 4.05 | 4.05 |
| 357.41 | 4.55 | 4.55 |
| 340.42 | 3.37 | 3.37 |
| 354.45 | 3.76 | 3.76 |
| 337.40 | 4.05 | 4.05 |
| 336.41 | 4.65 | 4.65 |
| 308.38 | 4.11 | 4.11 |
| 375.39 | 5.73 | 5.73 |
| 390.39 | 2.17 | 2.17 |
| 359.40 | 4.98 | 4.98 |
| 356.43 | 5.15 | 5.15 |
| 338.39 | 2.47 | 2.47 |
| 336.41 | 4.65 | 4.65 |
| 311.38 | 3.70 | 3.70 |
| 410.30 | 6.15 | 6.15 |
| 367.36 | 2.83 | 2.83 |
| 396.28 | 5.84 | 5.84 |
| 302.29 | 1.58 | 1.58 |
| 325.43 | 4.60 | 4.60 |
| 387.38 | 5.04 | 5.04 |
| 342.44 | 4.72 | 4.72 |
| 337.40 | 4.05 | 4.05 |
| 339.33 | 3.25 | 3.25 |
| 396.40 | 3.44 | 3.44 |
| 398.46 | 5.32 | 5.32 |
| 343.40 | 3.88 | 3.88 |
| 344.32 | 1.87 | 1.87 |
| 347.46 | 5.20 | 5.20 |
| 328.43 | 4.17 | 4.17 |
| 343.40 | 3.88 | 3.88 |
| 364.36 | 3.45 | 3.45 |
| 409.41 | 5.86 | 5.86 |
| 417.47 | 4.57 | 4.57 |
| 409.39 | 3.15 | 3.15 |
| 355.44 | 5.15 | 5.15 |
| 336.41 | 4.65 | 4.65 |
| 397.39 | 2.84 | 2.84 |
| 369.47 | 5.46 | 5.46 |
| 325.43 | 4.60 | 4.60 |
| 355.44 | 5.15 | 5.15 |
| 342.44 | 4.72 | 4.72 |
| 367.42 | 5.06 | 5.06 |
| 447.54 | 6.42 | 6.42 |
| 329.37 | 3.84 | 3.84 |