Basic Information
ID: ALA4731276
Type: Binding
Description: Inhibition of URAT1 in human RPTEC assessed as inhibition of [14C]uric acid uptake preincubated for 15 mins followed by [14C]uric acid addition and incubated under shaking condition for 2 hrs by scintillation counter method
Format: BAO_0000221
Organism: Homo sapiens
Cell type: RPTEC
Target: Solute carrier family 22 member 12(ALA6120)
Document: ALA4725450
Inhibition of URAT1 in human RPTEC assessed as inhibition of [14C]uric acid uptake preincubated for 15 mins followed by [14C]uric acid addition and incubated under shaking condition for 2 hrs by scintillation counter method: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4731276
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 424.09 | 5.46 | 5.46 |
| 358.20 | 3.09 | 3.09 |
| 354.39 | 2.53 | 2.53 |
| 350.32 | 3.99 | 3.99 |
| 298.73 | 3.12 | 3.12 |
| 391.75 | 3.46 | 3.46 |
| 338.34 | 1.64 | 1.64 |
| 320.39 | 3.76 | 3.76 |
| 382.32 | 2.67 | 2.67 |
| 360.42 | 2.38 | 2.38 |
| 289.29 | 2.34 | 2.34 |
| 369.85 | 3.16 | 3.16 |
| 387.33 | 2.81 | 2.81 |
| 264.28 | 2.47 | 2.47 |
| 341.75 | 2.58 | 2.58 |
| 290.32 | 3.52 | 3.52 |
| 356.40 | 2.78 | 2.78 |
| 294.31 | 2.48 | 2.48 |
| 310.38 | 3.19 | 3.19 |
| 348.77 | 2.31 | 2.31 |
| 342.38 | 2.22 | 2.22 |
| 353.78 | 2.45 | 2.45 |
| 304.35 | 3.34 | 3.34 |
| 390.18 | 3.07 | 3.07 |
| 332.28 | 3.49 | 3.49 |