Basic Information
ID: ALA4731278
Type: Toxicity
Description: Hepatotoxicity in rat liver mitochondria assessed as inhibition of mitochondrial respiration by measuring mitochondrial respiratory control ratio of oxygen consumption in presence of substrate and ADP to rate after complete conversion of ADP to ATP by Clark-type oxygen electrode method
Format: BAO_0000252
Organism: Rattus norvegicus
Tissue: Liver
Subcellular Fraction: Mitochondria
Target: ADMET(ALA612558)
Document: ALA4725450
Hepatotoxicity in rat liver mitochondria assessed as inhibition of mitochondrial respiration by measuring mitochondrial respiratory control ratio of oxygen consumption in presence of substrate and ADP to rate after complete conversion of ADP to ATP by Clark-type oxygen electrode method: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4731278
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 424.09 | 5.46 | 5.46 |
| 358.20 | 3.09 | 3.09 |
| 354.39 | 2.53 | 2.53 |
| 350.32 | 3.99 | 3.99 |
| 298.73 | 3.12 | 3.12 |
| 391.75 | 3.46 | 3.46 |
| 320.39 | 3.76 | 3.76 |
| 369.85 | 3.16 | 3.16 |
| 341.75 | 2.58 | 2.58 |
| 290.32 | 3.52 | 3.52 |
| 356.40 | 2.78 | 2.78 |
| 310.38 | 3.19 | 3.19 |
| 342.38 | 2.22 | 2.22 |
| 304.35 | 3.34 | 3.34 |
| 390.18 | 3.07 | 3.07 |