Prodrug activation in collagen/complete freund's adjuvant-induced rheumatoid arthritis DBA/1J mouse model assessed as Z)-2-((5-(1-cyclohexyl-1,6-dihyd...

ID: ALA4731515

Type: ADME

Description: Prodrug activation in collagen/complete freund's adjuvant-induced rheumatoid arthritis DBA/1J mouse model assessed as Z)-2-((5-(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)furan-2-yl)(hydroxy)methyl)-3-(dimethylamino)-3-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)oxy)acrylonitrile level in ankle joint at 10 mg/kg, ip by LC-MS/MS analysis

Format: BAO_0000218

Organism: Mus musculus

Strain: DBA/1J

Target:  ADMET(ALA612558)

Document:  ALA4725469

Prodrug activation in collagen/complete freund's adjuvant-induced rheumatoid arthritis DBA/1J mouse model assessed as Z)-2-((5-(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)furan-2-yl)(hydroxy)methyl)-3-(dimethylamino)-3-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)oxy)acrylonitrile level in ankle joint at 10 mg/kg, ip by LC-MS/MS analysis: 1