Basic Information
ID: ALA4731561
Type: Binding
Description: Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infected Sf9 insect cells assessed as reduction of S-adenosyl-L-homocysteine formation using human recombinant histone H2A (1 to 130 residues) and S-adenosyl-L-methionine as substrate after 60 mins by rapidfire mass spectrometry analysis
Organism: Homo sapiens
Cell type: Sf9
Activity Charts
Bioactivity
Activity Types for Assay ALA4731561
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 388.47 | -0.15 | -0.15 |
| 320.35 | -0.88 | -0.88 |
| 389.46 | -0.75 | -0.75 |
| 375.43 | -1.14 | -1.14 |
| 349.40 | -1.55 | -1.55 |
| 363.42 | -1.16 | -1.16 |
| 375.43 | -1.14 | -1.14 |
| 375.43 | -1.29 | -1.29 |
| 389.46 | -0.90 | -0.90 |
| 361.41 | -1.53 | -1.53 |
| 389.46 | -0.90 | -0.90 |
| 403.49 | -0.51 | -0.51 |
| 402.50 | 0.19 | 0.19 |
| 431.50 | -0.50 | -0.50 |
| 363.42 | -1.16 | -1.16 |
| 347.38 | -1.92 | -1.92 |
| 388.47 | 0.83 | 0.83 |