Basic Information
ID: ALA4731658
Type: Binding
Description: Inhibition of PI3Kgamma in human THP-1 cells assessed as reduction in Akt phosphorylation at S473 residue incubated for 60 mins measured after 120 mins by by alphalisa assay
Format: BAO_0000219
Organism: Homo sapiens
Cell type: THP-1
Target: PI3-kinase p110-gamma subunit(ALA3267)
Document: ALA4725475
Inhibition of PI3Kgamma in human THP-1 cells assessed as reduction in Akt phosphorylation at S473 residue incubated for 60 mins measured after 120 mins by by alphalisa assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4731658
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 476.50 | 6.37 | 6.37 |
| 519.52 | 6.68 | 6.68 |
| 396.49 | 5.35 | 5.35 |
| 465.55 | 5.97 | 5.97 |
| 423.52 | 4.94 | 4.94 |
| 519.52 | 6.68 | 6.68 |
| 490.59 | 3.29 | 3.29 |
| 462.53 | 6.46 | 6.46 |
| 422.53 | 5.74 | 5.74 |
| 479.58 | 6.27 | 6.27 |
| 439.56 | 5.51 | 5.51 |
| 450.54 | 5.06 | 5.06 |
| 465.48 | 5.40 | 5.40 |
| 505.62 | 6.84 | 6.84 |
| 451.53 | 5.66 | 5.66 |
| 451.53 | 5.66 | 5.66 |
| 454.53 | 3.74 | 3.74 |
| 545.56 | 6.79 | 6.79 |
| 438.53 | 4.66 | 4.66 |
| 411.51 | 4.69 | 4.69 |
| 431.93 | 5.04 | 5.04 |
| 479.58 | 5.90 | 5.90 |
| 451.53 | 5.66 | 5.66 |
| 458.56 | 4.20 | 4.20 |
| 432.53 | 5.83 | 5.83 |
| 493.61 | 6.78 | 6.78 |
| 422.53 | 5.74 | 5.74 |
| 465.55 | 5.59 | 5.59 |
| 466.59 | 5.58 | 5.58 |
| 504.62 | 3.64 | 3.64 |
| 486.60 | 4.61 | 4.61 |
| 475.57 | 3.79 | 3.79 |
| 533.55 | 6.99 | 6.99 |
| 493.61 | 6.32 | 6.32 |
| 454.53 | 4.34 | 4.34 |
| 408.51 | 5.35 | 5.35 |
| 490.59 | 3.76 | 3.76 |
| 422.41 | 5.12 | 5.12 |
| 408.51 | 5.35 | 5.35 |
| 481.55 | 5.67 | 5.67 |
| 434.54 | 5.74 | 5.74 |
| 427.51 | 4.39 | 4.39 |
| 412.49 | 4.59 | 4.59 |
| 520.63 | 6.26 | 6.26 |
| 400.53 | 4.37 | 4.37 |
| 491.59 | 6.08 | 6.08 |
| 451.53 | 4.94 | 4.94 |
| 465.55 | 5.97 | 5.97 |
| 424.50 | 4.74 | 4.74 |
| 422.49 | 4.26 | 4.26 |
| 375.43 | 3.99 | 3.99 |
| 491.59 | 6.54 | 6.54 |
| 469.52 | 5.80 | 5.80 |
| 408.51 | 5.35 | 5.35 |