Basic Information
ID: ALA4733961
Type: Binding
Description: Inhibition of NAE (unknown origin)-mediated neddylation assessed as suppression of cullin1-Nedd8 adduct formation at 25 uM preincubated for 10 mins followed by ATP addition and measured after 30 mins by immunoblot analysis relative to control
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4733961
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 610.67 | 6.32 | 6.32 |
| 396.45 | 4.33 | 4.33 |
| 443.53 | 2.06 | 2.06 |
| 543.63 | 5.30 | 5.30 |
| 529.60 | 5.26 | 5.26 |
| 521.63 | 5.39 | 5.39 |
| 515.58 | 5.58 | 5.58 |
| 559.59 | 5.31 | 5.31 |
| 545.60 | 5.19 | 5.19 |
| 582.67 | 5.78 | 5.78 |
| 571.69 | 6.08 | 6.08 |
| 622.53 | 6.07 | 6.07 |
| 588.63 | 5.21 | 5.21 |
| 612.52 | 6.61 | 6.61 |
| 479.54 | 4.22 | 4.22 |
| 519.57 | 4.85 | 4.85 |
| 579.66 | 4.79 | 4.79 |
| 605.70 | 6.85 | 6.85 |
| 578.08 | 5.96 | 5.96 |
| 578.08 | 5.96 | 5.96 |
| 610.67 | 6.32 | 6.32 |
| 626.67 | 6.48 | 6.48 |
| 507.60 | 5.00 | 5.00 |
| 547.59 | 5.40 | 5.40 |
| 573.66 | 5.31 | 5.31 |
| 525.57 | 3.62 | 3.62 |
| 557.66 | 5.61 | 5.61 |
| 579.61 | 5.58 | 5.58 |
| 578.72 | 5.37 | 5.37 |
| 610.67 | 6.32 | 6.32 |
| 611.70 | 6.86 | 6.86 |
| 511.59 | 4.10 | 4.10 |
| 545.60 | 5.59 | 5.59 |
| 516.57 | 4.98 | 4.98 |
| 594.66 | 4.23 | 4.23 |
| 481.56 | 4.47 | 4.47 |
| 612.52 | 6.61 | 6.61 |
| 533.57 | 5.72 | 5.72 |
| 573.61 | 4.99 | 4.99 |
| 612.52 | 6.61 | 6.61 |
| 624.70 | 6.33 | 6.33 |
| 524.63 | 4.01 | 4.01 |
| 542.63 | 7.14 | 7.14 |
| 587.64 | 5.03 | 5.03 |