Basic Information
ID: ALA4734521
Type: Binding
Description: Inhibition of ABCB1 in human resistant COLO 320 cells assessed as multidrug resistance reversing activity by measuring fluorescence activity ratio at 20 uM preincubated for 10 mins followed by rhodamine-123 addition and measured after 20 mins by flow cytometry
Format: BAO_0000221
Organism: Homo sapiens
Cell type: COLO 320
Target: P-glycoprotein 1(ALA4302)
Document: ALA4732098
Inhibition of ABCB1 in human resistant COLO 320 cells assessed as multidrug resistance reversing activity by measuring fluorescence activity ratio at 20 uM preincubated for 10 mins followed by rhodamine-123 addition and measured after 20 mins by flow cytometry: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4734521
Ratio
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 454.61 | 5.09 | 5.09 |
| 354.45 | 3.04 | 3.04 |
| 354.45 | 3.04 | 3.04 |
| 537.50 | 5.52 | 5.52 |
| 394.52 | 3.70 | 3.70 |
| 537.50 | 5.52 | 5.52 |
| 474.60 | 4.57 | 4.57 |
| 479.02 | 5.22 | 5.22 |
| 548.68 | 5.80 | 5.80 |
| 458.60 | 4.87 | 4.87 |
| 474.60 | 4.57 | 4.57 |
| 458.60 | 4.87 | 4.87 |
| 489.57 | 4.47 | 4.47 |
| 489.57 | 4.47 | 4.47 |
| 445.56 | 3.96 | 3.96 |
| 396.53 | 3.93 | 3.93 |
| 488.63 | 4.77 | 4.77 |
| 382.50 | 3.54 | 3.54 |
| 523.47 | 5.33 | 5.33 |
| 474.60 | 4.57 | 4.57 |
| 479.02 | 5.22 | 5.22 |
| 479.02 | 5.22 | 5.22 |
| 488.63 | 4.77 | 4.77 |
| 382.50 | 3.54 | 3.54 |
| 458.60 | 4.87 | 4.87 |
| 504.63 | 4.58 | 4.58 |
| 523.47 | 5.33 | 5.33 |
| 396.53 | 3.93 | 3.93 |
| 412.53 | 2.90 | 2.90 |