Basic Information
ID: ALA4734524
Type: Binding
Description: Potency index, ratio of compound FAR to verapamil FAR for inhibition of human ABCB1 expressed in mouse L5178Y-MDR cells assessed as multidrug resistance reversing activity by measuring fluorescence activity ratio at 2 uM preincubated for 10 mins followed by rhodamine-123 addition and measured after 20 mins by flow cytometry
Format: BAO_0000219
Organism: Homo sapiens
Cell type: L5178Y
Target: P-glycoprotein 1(ALA4302)
Document: ALA4732098
Potency index, ratio of compound FAR to verapamil FAR for inhibition of human ABCB1 expressed in mouse L5178Y-MDR cells assessed as multidrug resistance reversing activity by measuring fluorescence activity ratio at 2 uM preincubated for 10 mins followed by rhodamine-123 addition and measured after 20 mins by flow cytometry: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4734524
Ratio
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 537.50 | 5.52 | 5.52 |