Basic Information
ID: ALA4742485
Type: Binding
Description: Inhibition of CDK12 (686 to 1082 residues) /Cyclin K (unknown origin) using 5-FAM-CDK9tide peptide substrate incubated for 3 hrs
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4742485
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 362.36 | 3.20 | 3.20 |
| 327.82 | 3.44 | 3.44 |
| 327.82 | 3.44 | 3.44 |
| 319.37 | 2.06 | 2.06 |
| 441.46 | 4.30 | 4.30 |
| 606.67 | 3.63 | 3.63 |
| 399.52 | 2.75 | 2.75 |
| 455.49 | 4.52 | 4.52 |
| 418.42 | 2.78 | 2.78 |
| 508.57 | 3.93 | 3.93 |
| 458.49 | 3.80 | 3.80 |
| 462.48 | 3.24 | 3.24 |
| 465.46 | 4.84 | 4.84 |
| 353.86 | 3.78 | 3.78 |
| 427.43 | 4.20 | 4.20 |
| 542.48 | 3.95 | 3.95 |
| 538.60 | 3.30 | 3.30 |
| 333.44 | 3.67 | 3.67 |
| 499.54 | 4.44 | 4.44 |
| 510.47 | 3.26 | 3.26 |
| 403.92 | 4.90 | 4.90 |
| 375.40 | 4.05 | 4.05 |
| 440.27 | 4.57 | 4.57 |
| 343.82 | 2.41 | 2.41 |
| 353.86 | 3.78 | 3.78 |
| 352.83 | 3.31 | 3.31 |
| 409.42 | 4.90 | 4.90 |
| 437.41 | 4.06 | 4.06 |
| 454.46 | 4.58 | 4.58 |
| 409.42 | 4.90 | 4.90 |
| 441.46 | 4.21 | 4.21 |
| 458.49 | 4.04 | 4.04 |
| 556.57 | 3.65 | 3.65 |
| 335.46 | 3.66 | 3.66 |
| 396.80 | 3.86 | 3.86 |
| 488.52 | 6.02 | 6.02 |
| 471.44 | 2.85 | 2.85 |
| 439.46 | 3.21 | 3.21 |
| 467.52 | 3.85 | 3.85 |
| 419.45 | 3.93 | 3.93 |
| 453.49 | 3.55 | 3.55 |
| 419.41 | 2.56 | 2.56 |
| 429.49 | 5.51 | 5.51 |
| 405.38 | 3.51 | 3.51 |
| 452.44 | 3.86 | 3.86 |
| 456.45 | 5.01 | 5.01 |
| 348.41 | 2.01 | 2.01 |
| 441.46 | 4.51 | 4.51 |
| 475.44 | 3.80 | 3.80 |
| 516.55 | 4.12 | 4.12 |
| 510.54 | 2.72 | 2.72 |
| 355.87 | 4.22 | 4.22 |
| 335.41 | 2.99 | 2.99 |
| 345.81 | 3.58 | 3.58 |
| 369.86 | 3.64 | 3.64 |
| 323.40 | 2.14 | 2.14 |
| 419.27 | 3.39 | 3.39 |
| 346.80 | 2.98 | 2.98 |
| 385.90 | 3.80 | 3.80 |
| 373.38 | 3.81 | 3.81 |
| 488.51 | 3.40 | 3.40 |
| 478.48 | 4.24 | 4.24 |
| 441.46 | 4.51 | 4.51 |
| 488.51 | 3.40 | 3.40 |
| 453.49 | 3.22 | 3.22 |
| 459.44 | 4.14 | 4.14 |
| 439.45 | 4.26 | 4.26 |
| 340.41 | 2.89 | 2.89 |
| 389.43 | 4.44 | 4.44 |
| 335.46 | 3.66 | 3.66 |
| 438.56 | 3.02 | 3.02 |
| 483.50 | 3.79 | 3.79 |
| 477.49 | 5.35 | 5.35 |
| 323.40 | 2.80 | 2.80 |
| 404.37 | 3.63 | 3.63 |
| 481.52 | 5.87 | 5.87 |
| 364.43 | 3.36 | 3.36 |
| 464.47 | 3.08 | 3.08 |
| 427.43 | 3.99 | 3.99 |
| 341.85 | 3.75 | 3.75 |
| 427.43 | 4.20 | 4.20 |
| 364.48 | 3.38 | 3.38 |
| 497.46 | 4.70 | 4.70 |
| 427.57 | 3.53 | 3.53 |
| 395.82 | 4.46 | 4.46 |
| 325.39 | 3.24 | 3.24 |
| 478.48 | 5.05 | 5.05 |
| 347.43 | 2.62 | 2.62 |
| 339.42 | 3.30 | 3.30 |
| 453.49 | 3.35 | 3.35 |
| 400.41 | 3.69 | 3.69 |
| 510.47 | 3.26 | 3.26 |
| 389.43 | 4.59 | 4.59 |
| 474.49 | 3.01 | 3.01 |
| 508.55 | 5.11 | 5.11 |
| 447.51 | 4.51 | 4.51 |
| 362.44 | 2.57 | 2.57 |
| 377.37 | 2.78 | 2.78 |
| 474.49 | 3.01 | 3.01 |
| 468.48 | 4.36 | 4.36 |
| 502.54 | 3.79 | 3.79 |
| 341.85 | 3.69 | 3.69 |
| 341.80 | 2.97 | 2.97 |
| 337.43 | 2.84 | 2.84 |
| 402.38 | 2.65 | 2.65 |
| 386.38 | 3.68 | 3.68 |
| 468.51 | 3.06 | 3.06 |
| 467.52 | 3.99 | 3.99 |
| 504.52 | 5.00 | 5.00 |
| 341.85 | 3.69 | 3.69 |
| 426.45 | 4.60 | 4.60 |
| 361.37 | 3.81 | 3.81 |
| 468.48 | 4.36 | 4.36 |
| 399.52 | 2.75 | 2.75 |
| 430.48 | 4.41 | 4.41 |
| 397.35 | 4.05 | 4.05 |
| 389.43 | 4.44 | 4.44 |
| 403.92 | 4.97 | 4.97 |
| 437.41 | 4.06 | 4.06 |
| 389.43 | 4.44 | 4.44 |
| 380.35 | 3.34 | 3.34 |
| 387.41 | 4.34 | 4.34 |
| 389.43 | 4.59 | 4.59 |
| 458.98 | 3.35 | 3.35 |
| 345.81 | 3.39 | 3.39 |
| 412.93 | 3.28 | 3.28 |
| 317.40 | 2.77 | 2.77 |
| 385.90 | 3.56 | 3.56 |
| 438.46 | 4.87 | 4.87 |
| 488.52 | 6.02 | 6.02 |
| 497.46 | 4.70 | 4.70 |
| 341.85 | 3.83 | 3.83 |
| 506.53 | 5.36 | 5.36 |
| 488.51 | 3.67 | 3.67 |
| 438.46 | 4.87 | 4.87 |
| 455.49 | 4.52 | 4.52 |
| 403.92 | 4.84 | 4.84 |
| 493.49 | 4.34 | 4.34 |
| 375.40 | 4.05 | 4.05 |
| 380.35 | 3.34 | 3.34 |
| 411.39 | 3.55 | 3.55 |
| 347.43 | 2.62 | 2.62 |
| 341.85 | 3.75 | 3.75 |
| 468.44 | 4.11 | 4.11 |
| 418.42 | 2.78 | 2.78 |
| 491.52 | 5.36 | 5.36 |
| 384.39 | 3.26 | 3.26 |
| 389.43 | 4.59 | 4.59 |
| 341.85 | 3.75 | 3.75 |
| 403.45 | 4.83 | 4.83 |
| 441.46 | 4.21 | 4.21 |
| 483.50 | 3.79 | 3.79 |
| 459.48 | 3.68 | 3.68 |
| 383.93 | 4.81 | 4.81 |
| 502.54 | 3.79 | 3.79 |
| 418.42 | 2.78 | 2.78 |
| 369.90 | 4.56 | 4.56 |
| 474.49 | 2.77 | 2.77 |
| 341.85 | 3.69 | 3.69 |
| 401.49 | 2.60 | 2.60 |
| 456.47 | 5.08 | 5.08 |
| 307.40 | 3.10 | 3.10 |
| 473.54 | 5.22 | 5.22 |
| 369.90 | 4.50 | 4.50 |
| 477.44 | 5.07 | 5.07 |
| 529.57 | 7.27 | 7.27 |
| 457.50 | 4.74 | 4.74 |
| 439.46 | 3.21 | 3.21 |
| 509.56 | 5.67 | 5.67 |
| 441.46 | 4.21 | 4.21 |
| 404.37 | 3.82 | 3.82 |
| 414.44 | 4.46 | 4.46 |
| 363.51 | 4.30 | 4.30 |
| 559.52 | 6.38 | 6.38 |
| 468.48 | 4.17 | 4.17 |
| 335.46 | 3.91 | 3.91 |
| 427.43 | 4.20 | 4.20 |
| 468.51 | 3.06 | 3.06 |
| 457.45 | 3.51 | 3.51 |
| 472.47 | 3.22 | 3.22 |
| 328.81 | 2.84 | 2.84 |
| 443.45 | 5.12 | 5.12 |
| 455.49 | 4.52 | 4.52 |
| 335.46 | 3.81 | 3.81 |
| 339.42 | 3.49 | 3.49 |
| 438.46 | 4.87 | 4.87 |
| 463.51 | 5.98 | 5.98 |
| 395.82 | 4.46 | 4.46 |
| 537.52 | 5.70 | 5.70 |
| 322.42 | 2.75 | 2.75 |
| 494.55 | 6.08 | 6.08 |
| 453.49 | 3.60 | 3.60 |
| 402.38 | 2.65 | 2.65 |
| 430.92 | 2.72 | 2.72 |
| 456.48 | 3.91 | 3.91 |
| 371.83 | 3.14 | 3.14 |
| 414.44 | 4.41 | 4.41 |
| 426.45 | 4.60 | 4.60 |
| 346.44 | 3.22 | 3.22 |
| 459.52 | 4.83 | 4.83 |
| 363.80 | 3.72 | 3.72 |
| 385.49 | 2.93 | 2.93 |
| 376.39 | 3.29 | 3.29 |
| 479.53 | 4.09 | 4.09 |
| 427.43 | 4.20 | 4.20 |
| 516.55 | 4.12 | 4.12 |
| 477.49 | 5.35 | 5.35 |
| 460.99 | 2.68 | 2.68 |
| 468.48 | 4.36 | 4.36 |
| 488.52 | 6.02 | 6.02 |
| 481.52 | 5.01 | 5.01 |
| 545.49 | 6.37 | 6.37 |
| 451.47 | 3.07 | 3.07 |
| 488.51 | 3.67 | 3.67 |
| 542.48 | 3.95 | 3.95 |
| 431.42 | 3.15 | 3.15 |
| 404.37 | 3.63 | 3.63 |
| 328.81 | 2.84 | 2.84 |
| 495.51 | 5.25 | 5.25 |
| 452.48 | 5.18 | 5.18 |
| 432.45 | 3.18 | 3.18 |
| 534.59 | 5.71 | 5.71 |
| 480.49 | 4.57 | 4.57 |
| 442.45 | 3.90 | 3.90 |
| 412.93 | 3.28 | 3.28 |
| 502.54 | 3.79 | 3.79 |
| 341.85 | 3.83 | 3.83 |
| 444.49 | 4.93 | 4.93 |
| 418.42 | 2.78 | 2.78 |
| 400.46 | 3.98 | 3.98 |
| 341.85 | 3.69 | 3.69 |
| 495.57 | 4.58 | 4.58 |
| 328.81 | 2.84 | 2.84 |
| 403.45 | 4.83 | 4.83 |
| 403.41 | 4.01 | 4.01 |
| 441.46 | 4.21 | 4.21 |
| 477.44 | 5.07 | 5.07 |
| 497.46 | 4.70 | 4.70 |
| 328.81 | 2.61 | 2.61 |
| 464.46 | 4.14 | 4.14 |
| 451.46 | 4.67 | 4.67 |
| 340.41 | 2.89 | 2.89 |
| 439.45 | 4.26 | 4.26 |
| 459.52 | 4.83 | 4.83 |
| 427.43 | 4.20 | 4.20 |
| 341.85 | 3.83 | 3.83 |
| 418.42 | 3.17 | 3.17 |
| 418.42 | 3.17 | 3.17 |
| 453.49 | 3.60 | 3.60 |
| 386.38 | 3.68 | 3.68 |
| 430.43 | 3.76 | 3.76 |
| 467.43 | 4.38 | 4.38 |
| 397.35 | 4.09 | 4.09 |
| 398.34 | 3.48 | 3.48 |
| 337.43 | 2.84 | 2.84 |
| 473.54 | 5.22 | 5.22 |
| 439.45 | 4.26 | 4.26 |
| 337.43 | 2.84 | 2.84 |
| 319.41 | 3.43 | 3.43 |
| 455.46 | 5.61 | 5.61 |
| 424.53 | 2.63 | 2.63 |
| 401.40 | 3.08 | 3.08 |
| 454.48 | 2.72 | 2.72 |
| 431.51 | 5.54 | 5.54 |
| 341.85 | 3.78 | 3.78 |
| 478.48 | 4.24 | 4.24 |
| 372.27 | 3.55 | 3.55 |
| 331.42 | 2.78 | 2.78 |
| 387.37 | 3.07 | 3.07 |
| 375.40 | 4.12 | 4.12 |
| 321.43 | 3.35 | 3.35 |
| 465.48 | 4.68 | 4.68 |
| 393.44 | 4.40 | 4.40 |
| 467.52 | 3.94 | 3.94 |
| 345.81 | 3.58 | 3.58 |
| 447.51 | 4.51 | 4.51 |
| 375.40 | 4.05 | 4.05 |