Assay Report Card

Basic Information

ID: ALA4742612

Type: Binding

Description: Inhibition of CDK12/cyclinK (unknown origin) using RBER-IRStide as substrate and in presence of ATP preincubated for 30 mins followed by addition of substrate measured after 1 hr by ADP-Glo reagent assay

Organism: Homo sapiens

Activity Charts

Bioactivity

Activity Types for Assay ALA4742612

IC50

Total(192)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
334.38	2.10	2.10
249.28	2.58	2.58
431.50	2.33	2.33
499.96	4.08	4.08
415.46	2.07	2.07
443.51	2.40	2.40
437.89	1.94	1.94
515.60	2.78	2.78
392.46	1.80	1.80
467.53	2.46	2.46
455.52	2.77	2.77
234.26	3.11	3.11
542.64	2.32	2.32
479.54	4.25	4.25
443.51	2.50	2.50
497.56	3.61	3.61
332.37	2.30	2.30
415.46	1.58	1.58
477.96	2.82	2.82
506.57	3.36	3.36
441.54	3.27	3.27
368.42	1.85	1.85
463.93	2.76	2.76
415.46	1.89	1.89
478.52	3.42	3.42
499.96	4.08	4.08
213.24	1.84	1.84
463.93	2.76	2.76
304.36	2.35	2.35
451.49	3.00	3.00
443.51	2.50	2.50
509.57	3.88	3.88
365.39	2.80	2.80
429.48	2.31	2.31
304.36	2.35	2.35
469.55	3.16	3.16
477.53	4.03	4.03
437.46	3.33	3.33
475.51	3.47	3.47
309.33	2.30	2.30
491.98	3.21	3.21
526.65	2.94	2.94
325.33	1.00	1.00
414.47	2.12	2.12
349.40	1.56	1.56
445.48	1.34	1.34
249.28	2.58	2.58
335.41	2.04	2.04
269.70	2.93	2.93
469.55	3.01	3.01
494.00	3.19	3.19
443.51	2.36	2.36
404.48	1.14	1.14
427.47	2.14	2.14
443.51	2.45	2.45
477.53	4.03	4.03
392.46	1.80	1.80
389.46	2.46	2.46
333.40	1.68	1.68
477.53	4.03	4.03
443.51	2.36	2.36
477.53	4.03	4.03
467.53	3.98	3.98
415.46	1.72	1.72
265.28	2.28	2.28
451.49	3.37	3.37
500.61	2.43	2.43
265.28	1.76	1.76
401.47	2.40	2.40
451.49	3.00	3.00
455.52	2.81	2.81
534.62	3.96	3.96
306.33	1.97	1.97
278.32	1.77	1.77
235.25	2.27	2.27
451.49	3.35	3.35
499.53	5.32	5.32
429.48	2.11	2.11
457.54	2.70	2.70
265.28	2.28	2.28
375.44	1.68	1.68
457.54	2.84	2.84
304.36	2.35	2.35
477.96	2.82	2.82
392.46	1.80	1.80
445.48	1.34	1.34
469.55	3.01	3.01
447.47	2.06	2.06
430.47	2.54	2.54
249.28	2.58	2.58
415.46	2.07	2.07
526.65	2.94	2.94
455.52	2.50	2.50
477.53	4.03	4.03
445.48	1.34	1.34
455.52	2.77	2.77
334.38	2.66	2.66
443.51	2.45	2.45
491.98	3.07	3.07
465.52	3.71	3.71
486.58	2.04	2.04
469.55	3.03	3.03
506.57	3.36	3.36
499.96	4.08	4.08
276.30	2.26	2.26
451.49	3.67	3.67
433.52	3.33	3.33
443.51	2.50	2.50
540.67	3.34	3.34
275.31	2.87	2.87
429.48	2.31	2.31
443.51	2.70	2.70
499.96	4.08	4.08
415.46	1.92	1.92
451.92	2.16	2.16
391.44	1.22	1.22
404.47	4.00	4.00
482.55	2.78	2.78
312.76	2.43	2.43
235.25	2.27	2.27
238.29	2.13	2.13
349.40	1.45	1.45
305.34	2.88	2.88
445.48	1.34	1.34
479.54	2.84	2.84
443.51	2.50	2.50
451.49	3.37	3.37
429.48	2.11	2.11
249.28	2.58	2.58
475.55	5.47	5.47
445.48	1.34	1.34
534.62	3.96	3.96
512.62	2.57	2.57
485.94	4.02	4.02
278.28	1.37	1.37
429.48	2.31	2.31
429.48	2.36	2.36
477.53	4.03	4.03
535.61	3.35	3.35
454.49	2.88	2.88
494.56	3.26	3.26
508.59	3.30	3.30
389.46	2.46	2.46
306.37	2.42	2.42
443.51	2.50	2.50
441.50	1.95	1.95
335.42	1.92	1.92
326.36	3.52	3.52
475.51	3.47	3.47
484.56	2.09	2.09
415.46	1.92	1.92
431.46	1.21	1.21
443.51	2.36	2.36
500.61	2.43	2.43
235.25	2.50	2.50
336.36	1.65	1.65
212.26	2.45	2.45
443.51	2.75	2.75
443.51	2.36	2.36
292.30	1.63	1.63
439.48	3.55	3.55
477.96	3.01	3.01
469.55	3.16	3.16
507.55	4.04	4.04
455.52	2.77	2.77
457.54	2.89	2.89
540.67	3.34	3.34
528.62	1.81	1.81
499.96	4.08	4.08
433.47	0.91	0.91
437.46	3.33	3.33
403.45	1.62	1.62
429.48	2.16	2.16
382.42	2.35	2.35
325.38	3.86	3.86
234.26	2.88	2.88
433.47	0.91	0.91
455.52	2.77	2.77
443.51	2.75	2.75
249.28	2.58	2.58
347.43	2.02	2.02
442.48	1.84	1.84