Basic Information
ID: ALA4742634
Type: Binding
Description: Inhibition of CDK12/cyclin K (unknown origin) assessed as incoporation of [33]Pi using RBER-IRStide as substrate and in presence of [gamma-33P]-ATP measured after 60 mins by microplate scintillation counter
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4742634
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 446.51 | 2.82 | 2.82 |
| 444.50 | 2.57 | 2.57 |
| 472.55 | 3.17 | 3.17 |
| 429.48 | 2.87 | 2.87 |
| 462.55 | 3.44 | 3.44 |
| 387.44 | 3.08 | 3.08 |
| 419.46 | 3.53 | 3.53 |
| 445.48 | 3.17 | 3.17 |
| 432.48 | 2.40 | 2.40 |
| 423.90 | 3.96 | 3.96 |
| 435.92 | 4.12 | 4.12 |
| 421.89 | 3.73 | 3.73 |
| 405.43 | 3.22 | 3.22 |
| 405.43 | 3.03 | 3.03 |
| 388.43 | 2.48 | 2.48 |
| 419.46 | 3.53 | 3.53 |
| 430.47 | 2.18 | 2.18 |
| 407.45 | 3.44 | 3.44 |
| 417.47 | 3.09 | 3.09 |
| 435.92 | 4.12 | 4.12 |
| 484.60 | 3.35 | 3.35 |
| 418.46 | 2.16 | 2.16 |
| 401.47 | 3.39 | 3.39 |
| 458.52 | 2.78 | 2.78 |
| 401.47 | 3.33 | 3.33 |
| 390.45 | 2.70 | 2.70 |
| 419.49 | 3.31 | 3.31 |
| 474.57 | 3.02 | 3.02 |
| 401.47 | 3.47 | 3.47 |
| 387.44 | 3.08 | 3.08 |
| 405.43 | 3.22 | 3.22 |
| 401.47 | 3.11 | 3.11 |
| 433.47 | 3.00 | 3.00 |
| 481.58 | 3.10 | 3.10 |
| 386.45 | 3.69 | 3.69 |
| 460.54 | 3.01 | 3.01 |
| 431.45 | 2.78 | 2.78 |
| 407.45 | 3.44 | 3.44 |
| 458.57 | 3.40 | 3.40 |
| 458.57 | 3.32 | 3.32 |
| 401.47 | 3.39 | 3.39 |
| 417.47 | 3.09 | 3.09 |
| 404.43 | 1.77 | 1.77 |
| 389.46 | 3.30 | 3.30 |
| 415.50 | 3.86 | 3.86 |
| 423.50 | 2.84 | 2.84 |
| 444.54 | 3.01 | 3.01 |
| 405.43 | 3.22 | 3.22 |
| 388.43 | 2.48 | 2.48 |
| 385.43 | 2.53 | 2.53 |
| 401.47 | 3.39 | 3.39 |
| 462.53 | 3.15 | 3.15 |
| 412.45 | 2.95 | 2.95 |
| 460.54 | 3.21 | 3.21 |
| 403.49 | 3.61 | 3.61 |
| 458.57 | 3.04 | 3.04 |
| 427.51 | 3.42 | 3.42 |
| 437.93 | 4.35 | 4.35 |
| 415.50 | 3.78 | 3.78 |
| 462.53 | 3.15 | 3.15 |
| 479.56 | 2.87 | 2.87 |
| 421.89 | 3.73 | 3.73 |
| 423.90 | 3.96 | 3.96 |
| 419.46 | 3.61 | 3.61 |
| 486.58 | 2.80 | 2.80 |
| 437.93 | 4.35 | 4.35 |
| 465.54 | 2.48 | 2.48 |
| 373.42 | 2.69 | 2.69 |
| 433.51 | 3.70 | 3.70 |
| 479.56 | 2.79 | 2.79 |
| 421.48 | 3.83 | 3.83 |
| 415.50 | 3.78 | 3.78 |
| 423.42 | 3.36 | 3.36 |
| 478.98 | 3.67 | 3.67 |
| 419.49 | 3.31 | 3.31 |
| 417.47 | 3.09 | 3.09 |
| 467.55 | 2.71 | 2.71 |
| 399.45 | 2.92 | 2.92 |
| 431.50 | 3.48 | 3.48 |
| 401.47 | 3.39 | 3.39 |
| 421.89 | 3.73 | 3.73 |
| 431.50 | 3.48 | 3.48 |
| 406.45 | 1.99 | 1.99 |
| 417.47 | 3.09 | 3.09 |
| 405.43 | 3.22 | 3.22 |
| 388.47 | 3.91 | 3.91 |
| 400.48 | 4.08 | 4.08 |
| 414.47 | 3.18 | 3.18 |
| 403.49 | 3.70 | 3.70 |
| 419.46 | 3.61 | 3.61 |
| 448.53 | 3.05 | 3.05 |
| 405.43 | 3.22 | 3.22 |
| 402.50 | 4.30 | 4.30 |
| 474.57 | 3.02 | 3.02 |