Basic Information
ID: ALA4767044
Type: Binding
Description: Inhibition of HYSGRGK(Ac)GGK(Ac)GLGK(Ac)GGAK(Ac)RHRK(Biotin)-OH binding to recombinant human His6-tagged BRD4 bromodomain 1 (N44 to E168 residues) expressed in Escherichia coli BL21 (DE3) cells measured after 2 hrs by Alphascreen assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4767044
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 457.00 | 5.53 | 5.53 |
| 455.33 | 4.50 | 4.50 |
| 387.24 | 4.25 | 4.25 |
| 352.80 | 3.60 | 3.60 |
| 471.29 | 3.17 | 3.17 |
| 371.25 | 4.55 | 4.55 |
| 523.48 | 6.72 | 6.72 |
| 467.37 | 5.16 | 5.16 |
| 294.38 | 3.13 | 3.13 |
| 424.50 | 5.04 | 5.04 |
| 360.39 | 3.03 | 3.03 |
| 426.29 | 3.75 | 3.75 |
| 390.49 | 4.79 | 4.79 |
| 390.49 | 4.96 | 4.96 |
| 509.45 | 6.33 | 6.33 |
| 346.36 | 2.94 | 2.94 |
| 332.38 | 3.25 | 3.25 |
| 376.46 | 4.40 | 4.40 |
| 382.83 | 3.61 | 3.61 |
| 362.41 | 3.26 | 3.26 |
| 308.40 | 3.52 | 3.52 |
| 471.36 | 4.40 | 4.40 |
| 388.47 | 4.40 | 4.40 |
| 411.28 | 4.02 | 4.02 |
| 320.35 | 3.38 | 3.38 |
| 302.36 | 3.25 | 3.25 |
| 254.31 | 2.21 | 2.21 |
| 392.46 | 3.64 | 3.64 |
| 366.83 | 3.91 | 3.91 |
| 413.25 | 3.41 | 3.41 |
| 371.25 | 4.55 | 4.55 |
| 430.55 | 5.57 | 5.57 |
| 268.34 | 2.60 | 2.60 |
| 336.80 | 3.90 | 3.90 |
| 282.37 | 2.99 | 2.99 |
| 371.25 | 4.55 | 4.55 |
| 346.41 | 3.56 | 3.56 |
| 444.58 | 5.96 | 5.96 |
| 469.38 | 5.55 | 5.55 |
| 583.46 | 2.54 | 2.54 |
| 332.38 | 3.25 | 3.25 |
| 347.35 | 3.15 | 3.15 |
| 555.41 | 2.34 | 2.34 |
| 362.41 | 3.26 | 3.26 |
| 441.30 | 4.11 | 4.11 |
| 336.80 | 3.90 | 3.90 |
| 427.28 | 3.72 | 3.72 |
| 498.36 | 3.22 | 3.22 |
| 455.36 | 5.16 | 5.16 |
| 381.25 | 4.01 | 4.01 |