Basic Information
ID: ALA4767046
Type: Binding
Description: Binding affinity to human recombinant His6-tagged BRD4 bromodomain 1 (N44 to E168 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as change in melting temperature at 200 uM incubated for 30 mins by SYPRO orange dye based thermal shift assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4767046
Delta Tm
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 455.33 | 4.50 | 4.50 |
| 387.24 | 4.25 | 4.25 |
| 352.80 | 3.60 | 3.60 |
| 471.29 | 3.17 | 3.17 |
| 371.25 | 4.55 | 4.55 |
| 523.48 | 6.72 | 6.72 |
| 467.37 | 5.16 | 5.16 |
| 294.38 | 3.13 | 3.13 |
| 424.50 | 5.04 | 5.04 |
| 360.39 | 3.03 | 3.03 |
| 426.29 | 3.75 | 3.75 |
| 390.49 | 4.79 | 4.79 |
| 390.49 | 4.96 | 4.96 |
| 509.45 | 6.33 | 6.33 |
| 346.36 | 2.94 | 2.94 |
| 332.38 | 3.25 | 3.25 |
| 376.46 | 4.40 | 4.40 |
| 382.83 | 3.61 | 3.61 |
| 362.41 | 3.26 | 3.26 |
| 308.40 | 3.52 | 3.52 |
| 471.36 | 4.40 | 4.40 |
| 388.47 | 4.40 | 4.40 |
| 411.28 | 4.02 | 4.02 |
| 320.35 | 3.38 | 3.38 |
| 302.36 | 3.25 | 3.25 |
| 254.31 | 2.21 | 2.21 |
| 392.46 | 3.64 | 3.64 |
| 366.83 | 3.91 | 3.91 |
| 413.25 | 3.41 | 3.41 |
| 371.25 | 4.55 | 4.55 |
| 430.55 | 5.57 | 5.57 |
| 268.34 | 2.60 | 2.60 |
| 336.80 | 3.90 | 3.90 |
| 282.37 | 2.99 | 2.99 |
| 371.25 | 4.55 | 4.55 |
| 346.41 | 3.56 | 3.56 |
| 444.58 | 5.96 | 5.96 |
| 469.38 | 5.55 | 5.55 |
| 583.46 | 2.54 | 2.54 |
| 332.38 | 3.25 | 3.25 |
| 347.35 | 3.15 | 3.15 |
| 555.41 | 2.34 | 2.34 |
| 362.41 | 3.26 | 3.26 |
| 441.30 | 4.11 | 4.11 |
| 336.80 | 3.90 | 3.90 |
| 427.28 | 3.72 | 3.72 |
| 498.36 | 3.22 | 3.22 |
| 455.36 | 5.16 | 5.16 |
| 381.25 | 4.01 | 4.01 |