Basic Information
ID: ALA4767473
Type: ADME
Description: Prodrug conversion in rat liver S9 fraction assessed as release of active metabolite (R)-(6-chloro-4-(5-cyclopropyl-1H-pyrazol-3-ylamino)quinazolin-2-yl)(3-methylpiperazin-1-yl)methanone hydrochloride measured after 60 mins at 37 degC by LC-MS/MS analysis
Format: BAO_0000220
Organism: Rattus norvegicus
Tissue: Liver
Subcellular Fraction: S9 fraction
Target: ADMET(ALA612558)
Document: ALA4765244
Prodrug conversion in rat liver S9 fraction assessed as release of active metabolite (R)-(6-chloro-4-(5-cyclopropyl-1H-pyrazol-3-ylamino)quinazolin-2-yl)(3-methylpiperazin-1-yl)methanone hydrochloride measured after 60 mins at 37 degC by LC-MS/MS analysis: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4767473
Drug metabolism
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 587.30 | 5.28 | 5.28 |
| 570.05 | 4.46 | 4.46 |
| 556.02 | 4.07 | 4.07 |
| 483.96 | 3.93 | 3.93 |
| 546.03 | 5.11 | 5.11 |
| 570.05 | 4.46 | 4.46 |
| 512.01 | 4.71 | 4.71 |
| 469.93 | 3.54 | 3.54 |
| 497.99 | 4.32 | 4.32 |
| 584.08 | 4.85 | 4.85 |
| 526.04 | 5.10 | 5.10 |
| 512.01 | 4.57 | 4.57 |