Basic Information
ID: ALA4771751
Type: Binding
Description: Inhibition of recombinant human His6/SUMO-tagged HDAC8 expressed in Escherichia coli (BL21) DE3 pLysS assessed as residual activity at 50 uM using Boc-Lys(trifluoroacetyl)-AMC as substrate preincubated for 60 mins followed by substrate addition and measured after 60 mins by fluorescence assay relative to control
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4771751
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 399.45 | 3.87 | 3.87 |
| 329.34 | 2.35 | 2.35 |
| 333.33 | 2.25 | 2.25 |
| 373.35 | 2.86 | 2.86 |
| 425.24 | 3.86 | 3.86 |
| 486.14 | 4.48 | 4.48 |
| 443.23 | 4.00 | 4.00 |
| 346.34 | 3.09 | 3.09 |
| 335.37 | 2.41 | 2.41 |
| 407.25 | 3.72 | 3.72 |
| 397.24 | 4.26 | 4.26 |
| 364.33 | 3.23 | 3.23 |
| 358.38 | 2.96 | 2.96 |
| 438.47 | 2.75 | 2.75 |
| 342.38 | 3.26 | 3.26 |
| 346.34 | 3.09 | 3.09 |
| 420.45 | 4.75 | 4.75 |
| 396.35 | 3.97 | 3.97 |
| 385.43 | 3.56 | 3.56 |
| 346.34 | 3.09 | 3.09 |
| 430.79 | 4.63 | 4.63 |
| 430.79 | 4.63 | 4.63 |
| 376.82 | 3.92 | 3.92 |
| 328.35 | 2.95 | 2.95 |