Basic Information
ID: ALA4772125
Type: Binding
Description: Inhibition of RIPK1 in human FADD-deficient Jurkat I 2.1 cells assessed as protection against TNFalpha-induced necroptosis by measuring remaining viable cells at 10 uM measured after 24 hrs by MTS assay relative to TNFalpha
Format: BAO_0000221
Organism: Homo sapiens
Cell type: Jurkat I 2.1
Target: Receptor-interacting serine/threonine-protein kinase 1(ALA5464)
Document: ALA4765378
Inhibition of RIPK1 in human FADD-deficient Jurkat I 2.1 cells assessed as protection against TNFalpha-induced necroptosis by measuring remaining viable cells at 10 uM measured after 24 hrs by MTS assay relative to TNFalpha: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4772125
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 210.24 | 2.94 | 2.94 |
| 268.16 | 3.54 | 3.54 |
| 294.20 | 4.07 | 4.07 |
| 234.26 | 2.68 | 2.68 |
| 279.26 | 3.09 | 3.09 |
| 299.25 | 3.12 | 3.12 |
| 213.28 | 2.76 | 2.76 |
| 257.30 | 1.75 | 1.75 |
| 220.23 | 2.29 | 2.29 |
| 262.31 | 3.46 | 3.46 |
| 290.37 | 4.24 | 4.24 |
| 236.23 | 1.53 | 1.53 |
| 271.39 | 4.50 | 4.50 |
| 236.23 | 1.53 | 1.53 |
| 260.30 | 3.22 | 3.22 |
| 273.34 | 3.09 | 3.09 |
| 267.33 | 3.67 | 3.67 |
| 218.22 | 2.07 | 2.07 |
| 282.26 | 2.72 | 2.72 |
| 264.24 | 1.45 | 1.45 |
| 249.74 | 3.96 | 3.96 |
| 214.63 | 2.86 | 2.86 |
| 263.26 | 1.02 | 1.02 |
| 214.27 | 2.65 | 2.65 |
| 291.31 | 1.80 | 1.80 |
| 336.44 | 3.75 | 3.75 |
| 260.30 | 3.22 | 3.22 |
| 254.25 | 3.21 | 3.21 |
| 350.47 | 4.14 | 4.14 |
| 206.21 | 1.90 | 1.90 |
| 336.15 | 4.56 | 4.56 |
| 333.14 | 3.98 | 3.98 |
| 247.30 | 2.56 | 2.56 |
| 310.36 | 4.35 | 4.35 |
| 268.28 | 3.08 | 3.08 |
| 229.33 | 3.62 | 3.62 |
| 282.30 | 3.57 | 3.57 |
| 251.31 | 3.42 | 3.42 |
| 247.30 | 2.56 | 2.56 |
| 295.39 | 4.45 | 4.45 |
| 240.10 | 2.76 | 2.76 |
| 234.26 | 2.68 | 2.68 |
| 285.47 | ||
| 322.41 | 3.70 | 3.70 |
| 315.16 | 3.38 | 3.38 |
| 271.75 | 4.32 | 4.32 |
| 216.20 | 1.52 | 1.52 |
| 346.44 | 4.08 | 4.08 |
| 251.31 | 3.42 | 3.42 |
| 234.26 | 2.54 | 2.54 |
| 220.23 | 2.29 | 2.29 |
| 254.25 | 3.21 | 3.21 |
| 297.32 | 3.28 | 3.28 |
| 220.23 | 2.29 | 2.29 |
| 322.25 | 4.23 | 4.23 |
| 268.28 | 3.08 | 3.08 |