Basic Information
ID: ALA4774179
Type: Binding
Description: Inhibition of recombinant human GST-tagged RET cytoplasmic domain (658 to 1114 residues) expressed in baculovirus expression system using 5-FAM-EEPLYWSFPAKKK-CONH2 as substrate preincubated for 60 mins followed by substrate addition by microfluidic assay
Format: BAO_0000019
Organism: Homo sapiens
Target: Tyrosine-protein kinase receptor RET(ALA2041)
Document: ALA4765434
Inhibition of recombinant human GST-tagged RET cytoplasmic domain (658 to 1114 residues) expressed in baculovirus expression system using 5-FAM-EEPLYWSFPAKKK-CONH2 as substrate preincubated for 60 mins followed by substrate addition by microfluidic assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4774179
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 411.39 | 4.90 | 4.90 |
| 472.57 | 5.90 | 5.90 |
| 485.62 | 5.64 | 5.64 |
| 390.45 | 4.17 | 4.17 |
| 357.42 | 3.56 | 3.56 |
| 321.38 | 2.91 | 2.91 |
| 403.49 | 3.91 | 3.91 |
| 445.83 | 5.55 | 5.55 |
| 394.44 | 4.43 | 4.43 |
| 509.61 | 5.59 | 5.59 |
| 361.38 | 4.02 | 4.02 |
| 421.48 | 3.29 | 3.29 |
| 417.52 | 3.92 | 3.92 |
| 404.47 | 4.18 | 4.18 |
| 470.54 | 4.57 | 4.57 |
| 385.47 | 5.01 | 5.01 |
| 443.51 | 5.75 | 5.75 |
| 390.45 | 4.17 | 4.17 |
| 493.59 | 6.99 | 6.99 |
| 427.39 | 4.78 | 4.78 |
| 487.59 | 5.30 | 5.30 |
| 483.58 | 4.31 | 4.31 |
| 433.47 | 3.91 | 3.91 |
| 465.56 | 5.41 | 5.41 |
| 307.36 | 2.52 | 2.52 |
| 544.64 | 5.24 | 5.24 |
| 522.65 | 7.13 | 7.13 |
| 467.50 | 5.70 | 5.70 |
| 441.47 | 4.42 | 4.42 |
| 508.58 | 6.04 | 6.04 |
| 399.50 | 5.18 | 5.18 |
| 557.68 | 4.98 | 4.98 |
| 387.40 | 3.61 | 3.61 |
| 395.83 | 4.68 | 4.68 |
| 420.54 | 4.65 | 4.65 |
| 407.50 | 4.90 | 4.90 |
| 491.60 | 6.68 | 6.68 |
| 467.50 | 5.70 | 5.70 |
| 403.49 | 3.91 | 3.91 |
| 500.63 | 5.05 | 5.05 |
| 395.83 | 4.68 | 4.68 |
| 378.43 | 4.76 | 4.76 |