Basic Information
ID: ALA4775281
Type: Binding
Description: Inhibition of NLRP3 in PMA-stimulated human THP-1 cells assessed as reduction in IL-1beta release at 20 uM pre-treated for 24 hrs followed by stimulation with LPS for 3 hrs and ATP for 1 hr by ELISA analysis
Format: BAO_0000221
Organism: Homo sapiens
Cell type: THP-1
Target: NACHT, LRR and PYD domains-containing protein 3(ALA1741208)
Document: ALA4765468
Inhibition of NLRP3 in PMA-stimulated human THP-1 cells assessed as reduction in IL-1beta release at 20 uM pre-treated for 24 hrs followed by stimulation with LPS for 3 hrs and ATP for 1 hr by ELISA analysis: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4775281
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 382.49 | 0.12 | 0.12 |
| 434.58 | 3.47 | 3.47 |
| 542.61 | 3.26 | 3.26 |
| 542.61 | 3.26 | 3.26 |
| 642.62 | 5.02 | 5.02 |
| 438.59 | 1.68 | 1.68 |
| 700.77 | 1.46 | 1.46 |
| 542.61 | 3.26 | 3.26 |
| 606.75 | 5.29 | 5.29 |
| 664.42 | 4.51 | 4.51 |
| 622.70 | 2.56 | 2.56 |
| 534.68 | 3.60 | 3.60 |
| 410.54 | 0.90 | 0.90 |
| 618.84 | 5.58 | 5.58 |
| 556.65 | 2.73 | 2.73 |
| 778.62 | 7.06 | 7.06 |
| 534.68 | 3.27 | 3.27 |
| 620.73 | 2.90 | 2.90 |
| 566.68 | 3.00 | 3.00 |
| 606.75 | 5.29 | 5.29 |
| 448.61 | 3.86 | 3.86 |
| 658.82 | 6.32 | 6.32 |
| 506.63 | 2.98 | 2.98 |
| 575.52 | 4.29 | 4.29 |
| 590.70 | 3.39 | 3.39 |
| 596.62 | 2.80 | 2.80 |
| 408.55 | 3.12 | 3.12 |
| 508.60 | 1.77 | 1.77 |
| 518.69 | 3.11 | 3.11 |
| 466.65 | 2.46 | 2.46 |
| 596.62 | 2.80 | 2.80 |
| 422.57 | 3.51 | 3.51 |