Basic Information
ID: ALA4775286
Type: Binding
Description: Inhibition of NLRP3 in PMA-stimulated human THP-1 cells assessed as reduction in IL-1beta release pre-treated for 24 hrs followed by stimulation with LPS for 3 hrs and ATP for 1 hr by ELISA analysis
Organism: Homo sapiens
Cell type: THP-1
Activity Charts
Bioactivity
Activity Types for Assay ALA4775286
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 700.77 | 1.46 | 1.46 |
| 618.84 | 5.58 | 5.58 |
| 658.82 | 6.32 | 6.32 |
| 590.70 | 3.39 | 3.39 |
| 596.62 | 2.80 | 2.80 |
| 466.65 | 2.46 | 2.46 |