Inhibition of NLRP3 inflammasome activation in PMA-stimulated human THP-1 cells assessed as reduction in cleaved p20 subunit of active caspase-1 secre...

ID: ALA4775288

Type: Binding

Description: Inhibition of NLRP3 inflammasome activation in PMA-stimulated human THP-1 cells assessed as reduction in cleaved p20 subunit of active caspase-1 secretion at 15 to 45 uM pre-treated for 24 hrs followed by stimulation with LPS for 3 hrs and ATP for 1 hr by Western blot analysis

Format: BAO_0000221

Organism: Homo sapiens

Cell type: THP-1

Target:  NACHT, LRR and PYD domains-containing protein 3(ALA1741208)

Document:  ALA4765468

Inhibition of NLRP3 inflammasome activation in PMA-stimulated human THP-1 cells assessed as reduction in cleaved p20 subunit of active caspase-1 secretion at 15 to 45 uM pre-treated for 24 hrs followed by stimulation with LPS for 3 hrs and ATP for 1 hr by Western blot analysis: 1