Basic Information
ID: ALA4775291
Type: Binding
Description: Inhibition of NLRP3 inflammasome activation in PMA-stimulated human THP-1 cells assessed as reduction in IL-1beta secretion at 5 to 15 uM pre-treated for 24 hrs followed by stimulation with LPS for 3 hrs and nigericin for 1 hr by ELISA analysis
Organism: Homo sapiens
Cell type: THP-1
Activity Charts
Bioactivity
Activity Types for Assay ALA4775291
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 590.70 | 3.39 | 3.39 |