Basic Information
ID: ALA4808118
Type: Functional
Description: Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
Format: BAO_0000219
Organism: Homo sapiens
Cell type: HEK
Target: Mas-related G-protein coupled receptor member X4(ALA4523430)
Document: ALA4806969
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay: 38
Activity Charts
Bioactivity
Activity Types for Assay ALA4808118
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 258.27 | 2.97 | 2.97 |
| 278.31 | 4.12 | 4.12 |
| 268.31 | 3.45 | 3.45 |
| 287.10 | 3.86 | 3.86 |
| 262.69 | 3.62 | 3.62 |
| 272.30 | 3.36 | 3.36 |
| 364.24 | 5.00 | 5.00 |
| 279.30 | 3.51 | 3.51 |
| 278.25 | 3.55 | 3.55 |
| 246.24 | 3.10 | 3.10 |
| 287.70 | 3.49 | 3.49 |
| 291.73 | 3.41 | 3.41 |
| 297.14 | 4.27 | 4.27 |
| 282.30 | 3.09 | 3.09 |
| 330.69 | 4.64 | 4.64 |
| 294.25 | 3.25 | 3.25 |
| 331.68 | 4.03 | 4.03 |
| 348.68 | 4.78 | 4.78 |
| 276.72 | 3.93 | 3.93 |
| 344.72 | 4.72 | 4.72 |
| 314.23 | 4.12 | 4.12 |
| 260.26 | 3.41 | 3.41 |
| 328.26 | 4.43 | 4.43 |
| 292.72 | 3.63 | 3.63 |
| 297.14 | 4.27 | 4.27 |
| 280.68 | 3.76 | 3.76 |
| 348.68 | 4.78 | 4.78 |
| 365.13 | 5.29 | 5.29 |
| 280.68 | 3.76 | 3.76 |
| 287.70 | 3.49 | 3.49 |
| 326.27 | 3.95 | 3.95 |
| 278.25 | 3.90 | 3.90 |
| 327.16 | 4.28 | 4.28 |
| 327.16 | 4.28 | 4.28 |
| 284.34 | 4.18 | 4.18 |
| 330.69 | 4.64 | 4.64 |
| 308.24 | 3.29 | 3.29 |
| 277.71 | 3.32 | 3.32 |
| 279.30 | 3.51 | 3.51 |
| 293.32 | 3.75 | 3.75 |
| 320.34 | 4.76 | 4.76 |
| 294.71 | 4.06 | 4.06 |
| 304.35 | 4.63 | 4.63 |
| 331.58 | 4.92 | 4.92 |
| 311.16 | 4.58 | 4.58 |
| 302.11 | 3.35 | 3.35 |
| 280.68 | 3.76 | 3.76 |
| 313.14 | 3.15 | 3.15 |
| 287.70 | 3.49 | 3.49 |
| 318.37 | 4.94 | 4.94 |
| 321.25 | 3.85 | 3.85 |
| 268.31 | 3.84 | 3.84 |
| 272.30 | 3.36 | 3.36 |
| 297.14 | 4.27 | 4.27 |
| 312.24 | 3.86 | 3.86 |
| 268.31 | 3.45 | 3.45 |
| 314.23 | 4.12 | 4.12 |
| 263.68 | 3.01 | 3.01 |
| 253.26 | 2.84 | 2.84 |
| 258.27 | 2.97 | 2.97 |
| 260.26 | 3.41 | 3.41 |
| 308.24 | 3.29 | 3.29 |
| 330.69 | 4.64 | 4.64 |
| 296.24 | 3.98 | 3.98 |
| 298.38 | 4.57 | 4.57 |
| 292.72 | 3.63 | 3.63 |
| 331.58 | 4.92 | 4.92 |
| 287.70 | 3.49 | 3.49 |
| 296.32 | 3.48 | 3.48 |
| 267.28 | 3.14 | 3.14 |
| 345.70 | 4.12 | 4.12 |
| 310.27 | 4.29 | 4.29 |
| 311.16 | 4.36 | 4.36 |
| 303.17 | 4.33 | 4.33 |
| 274.29 | 3.72 | 3.72 |
| 322.33 | 4.77 | 4.77 |
| 270.28 | 3.17 | 3.17 |
| 301.73 | 3.58 | 3.58 |
| 348.68 | 4.78 | 4.78 |
| 270.33 | 4.09 | 4.09 |
| 344.72 | 4.72 | 4.72 |
| 260.26 | 3.19 | 3.19 |
| 293.32 | 3.60 | 3.60 |
| 258.27 | 2.97 | 2.97 |
| 262.69 | 3.62 | 3.62 |
| 276.72 | 3.93 | 3.93 |
| 317.19 | 4.42 | 4.42 |
| 348.68 | 4.78 | 4.78 |
| 296.30 | 4.26 | 4.26 |
| 345.70 | 4.12 | 4.12 |
| 260.26 | 3.41 | 3.41 |
| 278.31 | 4.12 | 4.12 |
| 290.75 | 4.23 | 4.23 |
| 297.23 | 3.38 | 3.38 |
| 280.68 | 3.76 | 3.76 |
| 331.68 | 4.03 | 4.03 |
| 326.27 | 3.99 | 3.99 |
| 327.38 | 2.89 | 2.89 |
| 365.13 | 5.29 | 5.29 |
| 299.35 | 3.66 | 3.66 |