Basic Information
ID: ALA4808118
Type: Functional
Description: Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
Organism: Homo sapiens
Cell type: HEK
Activity Charts
Bioactivity
Activity Types for Assay ALA4808118
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 258.27 | 2.97 | 2.97 |
| 278.31 | 4.12 | 4.12 |
| 268.31 | 3.45 | 3.45 |
| 287.10 | 3.86 | 3.86 |
| 262.69 | 3.62 | 3.62 |
| 272.30 | 3.36 | 3.36 |
| 313.21 | 4.98 | 4.98 |
| 364.24 | 5.00 | 5.00 |
| 370.75 | 5.51 | 5.51 |
| 346.69 | 4.52 | 4.52 |
| 307.14 | 3.73 | 3.73 |
| 279.30 | 3.51 | 3.51 |
| 312.75 | 4.77 | 4.77 |
| 358.74 | 5.20 | 5.20 |
| 349.57 | 5.06 | 5.06 |
| 331.68 | 4.03 | 4.03 |
| 355.71 | 3.51 | 3.51 |
| 368.74 | 4.19 | 4.19 |
| 407.80 | 3.63 | 3.63 |
| 336.31 | 4.86 | 4.86 |
| 328.26 | 4.43 | 4.43 |
| 302.76 | 4.49 | 4.49 |
| 355.74 | 4.22 | 4.22 |
| 278.25 | 3.55 | 3.55 |
| 246.24 | 3.10 | 3.10 |
| 297.14 | 4.27 | 4.27 |
| 256.30 | 3.58 | 3.58 |
| 425.83 | 4.80 | 4.80 |
| 386.76 | 3.15 | 3.15 |
| 287.70 | 3.49 | 3.49 |
| 409.58 | 5.40 | 5.40 |
| 322.15 | 4.14 | 4.14 |
| 356.59 | 4.80 | 4.80 |
| 411.81 | 4.41 | 4.41 |
| 302.33 | 4.32 | 4.32 |
| 291.73 | 3.41 | 3.41 |
| 268.27 | 3.71 | 3.71 |
| 330.74 | 4.91 | 4.91 |
| 341.59 | 4.38 | 4.38 |
| 297.14 | 4.27 | 4.27 |
| 282.30 | 3.09 | 3.09 |
| 330.69 | 4.64 | 4.64 |
| 352.74 | 5.33 | 5.33 |
| 294.25 | 3.25 | 3.25 |
| 311.16 | 4.58 | 4.58 |
| 293.32 | 3.82 | 3.82 |
| 331.68 | 4.03 | 4.03 |
| 312.70 | 4.55 | 4.55 |
| 345.70 | 4.34 | 4.34 |
| 348.68 | 4.78 | 4.78 |
| 276.72 | 3.93 | 3.93 |
| 344.72 | 4.72 | 4.72 |
| 314.23 | 4.12 | 4.12 |
| 296.24 | 3.98 | 3.98 |
| 348.68 | 4.78 | 4.78 |
| 296.32 | 3.48 | 3.48 |
| 297.14 | 4.27 | 4.27 |
| 353.73 | 4.72 | 4.72 |
| 415.80 | 4.53 | 4.53 |
| 372.71 | 4.26 | 4.26 |
| 427.85 | 5.19 | 5.19 |
| 311.16 | 4.41 | 4.41 |
| 371.70 | 4.39 | 4.39 |
| 260.26 | 3.41 | 3.41 |
| 347.68 | 3.91 | 3.91 |
| 315.13 | 4.41 | 4.41 |
| 292.33 | 4.43 | 4.43 |
| 387.74 | 3.75 | 3.75 |
| 304.71 | 3.24 | 3.24 |
| 328.26 | 4.43 | 4.43 |
| 292.72 | 3.63 | 3.63 |
| 297.14 | 4.27 | 4.27 |
| 387.79 | 4.31 | 4.31 |
| 307.14 | 3.73 | 3.73 |
| 326.27 | 4.17 | 4.17 |
| 277.32 | 4.15 | 4.15 |
| 280.68 | 3.76 | 3.76 |
| 267.28 | 3.03 | 3.03 |
| 338.26 | 4.10 | 4.10 |
| 372.71 | 4.26 | 4.26 |
| 354.72 | 4.12 | 4.12 |
| 311.69 | 4.81 | 4.81 |
| 348.68 | 4.78 | 4.78 |
| 278.25 | 3.90 | 3.90 |
| 304.35 | 4.63 | 4.63 |
| 325.34 | 4.20 | 4.20 |
| 334.30 | 3.77 | 3.77 |
| 366.74 | 4.18 | 4.18 |
| 315.13 | 4.41 | 4.41 |
| 297.14 | 4.27 | 4.27 |
| 365.13 | 5.29 | 5.29 |
| 493.87 | 5.07 | 5.07 |
| 359.73 | 4.51 | 4.51 |
| 427.85 | 4.97 | 4.97 |
| 301.69 | 4.52 | 4.52 |
| 280.68 | 3.76 | 3.76 |
| 427.85 | 4.97 | 4.97 |
| 349.69 | 4.33 | 4.33 |
| 324.30 | 4.60 | 4.60 |
| 338.26 | 3.60 | 3.60 |
| 406.79 | 6.30 | 6.30 |
| 329.71 | 4.04 | 4.04 |
| 287.70 | 3.49 | 3.49 |
| 423.80 | 3.51 | 3.51 |
| 326.27 | 3.95 | 3.95 |
| 278.25 | 3.90 | 3.90 |
| 398.69 | 5.65 | 5.65 |
| 327.16 | 4.28 | 4.28 |
| 308.33 | 4.13 | 4.13 |
| 360.62 | 4.88 | 4.88 |
| 346.60 | 4.63 | 4.63 |
| 349.79 | 4.36 | 4.36 |
| 327.16 | 4.28 | 4.28 |
| 315.13 | 4.41 | 4.41 |
| 327.16 | 4.28 | 4.28 |
| 359.73 | 4.59 | 4.59 |
| 331.68 | 4.03 | 4.03 |
| 327.16 | 4.28 | 4.28 |
| 305.69 | 3.63 | 3.63 |
| 368.74 | 5.30 | 5.30 |
| 284.34 | 4.18 | 4.18 |
| 429.82 | 4.78 | 4.78 |
| 283.11 | 4.48 | 4.48 |
| 330.69 | 4.64 | 4.64 |
| 308.24 | 3.29 | 3.29 |
| 296.15 | 3.67 | 3.67 |
| 277.71 | 3.32 | 3.32 |
| 279.30 | 3.51 | 3.51 |
| 349.57 | 5.06 | 5.06 |
| 331.58 | 4.92 | 4.92 |
| 293.32 | 3.75 | 3.75 |
| 322.15 | 4.14 | 4.14 |
| 297.23 | 3.38 | 3.38 |
| 405.80 | 6.19 | 6.19 |
| 320.34 | 4.76 | 4.76 |
| 294.71 | 4.06 | 4.06 |
| 280.68 | 3.76 | 3.76 |
| 304.35 | 4.63 | 4.63 |
| 344.72 | 4.37 | 4.37 |
| 400.78 | 3.41 | 3.41 |
| 400.83 | 4.23 | 4.23 |
| 431.79 | 3.50 | 3.50 |
| 331.58 | 4.92 | 4.92 |
| 344.72 | 4.94 | 4.94 |
| 360.71 | 4.82 | 4.82 |
| 410.57 | 4.79 | 4.79 |
| 311.16 | 4.58 | 4.58 |
| 401.81 | 4.70 | 4.70 |
| 419.83 | 5.87 | 5.87 |
| 315.13 | 4.41 | 4.41 |
| 362.71 | 4.86 | 4.86 |
| 302.11 | 3.35 | 3.35 |
| 280.68 | 3.76 | 3.76 |
| 313.14 | 3.15 | 3.15 |
| 297.14 | 4.27 | 4.27 |
| 330.69 | 4.06 | 4.06 |
| 310.27 | 4.29 | 4.29 |
| 287.70 | 3.49 | 3.49 |
| 268.27 | 3.71 | 3.71 |
| 318.37 | 4.94 | 4.94 |
| 366.67 | 4.91 | 4.91 |
| 329.70 | 4.67 | 4.67 |
| 354.72 | 4.12 | 4.12 |
| 278.25 | 3.90 | 3.90 |
| 314.23 | 4.12 | 4.12 |
| 321.25 | 3.85 | 3.85 |
| 268.31 | 3.84 | 3.84 |
| 356.69 | 3.90 | 3.90 |
| 272.30 | 3.36 | 3.36 |
| 282.17 | 4.03 | 4.03 |
| 297.14 | 4.27 | 4.27 |
| 312.24 | 3.86 | 3.86 |
| 268.31 | 3.45 | 3.45 |
| 386.80 | 3.89 | 3.89 |
| 314.23 | 4.12 | 4.12 |
| 401.77 | 4.14 | 4.14 |
| 263.68 | 3.01 | 3.01 |
| 296.24 | 4.04 | 4.04 |
| 302.34 | 3.60 | 3.60 |
| 307.35 | 4.07 | 4.07 |
| 253.26 | 2.84 | 2.84 |
| 258.27 | 2.97 | 2.97 |
| 315.13 | 4.41 | 4.41 |
| 260.26 | 3.41 | 3.41 |
| 308.24 | 3.29 | 3.29 |
| 330.69 | 4.64 | 4.64 |
| 296.24 | 3.98 | 3.98 |
| 276.72 | 3.93 | 3.93 |
| 311.16 | 4.58 | 4.58 |
| 354.72 | 4.12 | 4.12 |
| 298.38 | 4.57 | 4.57 |
| 297.14 | 4.27 | 4.27 |
| 292.72 | 3.63 | 3.63 |
| 331.58 | 4.92 | 4.92 |
| 329.37 | 4.01 | 4.01 |
| 376.73 | 5.25 | 5.25 |
| 398.69 | 5.65 | 5.65 |
| 444.79 | 3.00 | 3.00 |
| 287.70 | 3.49 | 3.49 |
| 372.71 | 4.26 | 4.26 |
| 296.32 | 3.48 | 3.48 |
| 267.28 | 3.14 | 3.14 |
| 345.70 | 4.12 | 4.12 |
| 385.81 | 5.47 | 5.47 |
| 373.76 | 4.98 | 4.98 |
| 310.27 | 4.29 | 4.29 |
| 296.30 | 4.26 | 4.26 |
| 311.16 | 4.36 | 4.36 |
| 303.17 | 4.33 | 4.33 |
| 274.29 | 3.72 | 3.72 |
| 296.15 | 4.30 | 4.30 |
| 322.33 | 4.77 | 4.77 |
| 284.34 | 4.18 | 4.18 |
| 345.76 | 4.55 | 4.55 |
| 516.90 | 5.84 | 5.84 |
| 375.14 | 4.75 | 4.75 |
| 300.75 | 3.41 | 3.41 |
| 355.70 | 4.51 | 4.51 |
| 372.77 | 3.63 | 3.63 |
| 298.29 | 2.85 | 2.85 |
| 371.74 | 4.91 | 4.91 |
| 346.69 | 4.52 | 4.52 |
| 314.23 | 4.12 | 4.12 |
| 285.30 | 2.32 | 2.32 |
| 311.16 | 4.58 | 4.58 |
| 411.76 | 5.60 | 5.60 |
| 335.28 | 4.16 | 4.16 |
| 387.79 | 4.05 | 4.05 |
| 270.28 | 3.17 | 3.17 |
| 373.76 | 3.66 | 3.66 |
| 301.73 | 3.58 | 3.58 |
| 349.67 | 4.17 | 4.17 |
| 304.73 | 3.82 | 3.82 |
| 348.68 | 4.78 | 4.78 |
| 270.33 | 4.09 | 4.09 |
| 385.77 | 4.37 | 4.37 |
| 344.72 | 4.72 | 4.72 |
| 331.58 | 4.92 | 4.92 |
| 467.83 | 4.09 | 4.09 |
| 449.81 | 5.89 | 5.89 |
| 343.73 | 4.30 | 4.30 |
| 294.25 | 3.57 | 3.57 |
| 349.67 | 4.17 | 4.17 |
| 413.82 | 4.53 | 4.53 |
| 283.15 | 4.06 | 4.06 |
| 458.82 | 3.39 | 3.39 |
| 260.26 | 3.19 | 3.19 |
| 293.32 | 3.60 | 3.60 |
| 353.73 | 4.72 | 4.72 |
| 385.77 | 3.75 | 3.75 |
| 258.27 | 2.97 | 2.97 |
| 262.69 | 3.62 | 3.62 |
| 311.26 | 3.69 | 3.69 |
| 311.16 | 4.20 | 4.20 |
| 298.12 | 3.67 | 3.67 |
| 371.79 | 5.08 | 5.08 |
| 322.15 | 4.14 | 4.14 |
| 276.72 | 3.93 | 3.93 |
| 352.74 | 5.33 | 5.33 |
| 315.13 | 4.41 | 4.41 |
| 296.24 | 3.98 | 3.98 |
| 369.77 | 4.57 | 4.57 |
| 317.19 | 4.42 | 4.42 |
| 355.61 | 4.41 | 4.41 |
| 329.75 | 4.66 | 4.66 |
| 355.74 | 4.50 | 4.50 |
| 278.14 | 4.44 | 4.44 |
| 370.72 | 4.00 | 4.00 |
| 348.68 | 4.78 | 4.78 |
| 364.68 | 4.65 | 4.65 |
| 437.82 | 3.56 | 3.56 |
| 417.77 | 3.11 | 3.11 |
| 296.30 | 4.26 | 4.26 |
| 360.71 | 4.64 | 4.64 |
| 293.66 | 3.74 | 3.74 |
| 364.68 | 4.65 | 4.65 |
| 344.72 | 4.94 | 4.94 |
| 345.70 | 4.12 | 4.12 |
| 260.26 | 3.41 | 3.41 |
| 336.69 | 5.88 | 5.88 |
| 347.68 | 3.91 | 3.91 |
| 278.31 | 4.12 | 4.12 |
| 290.75 | 4.23 | 4.23 |
| 267.28 | 3.14 | 3.14 |
| 353.73 | 4.71 | 4.71 |
| 276.72 | 3.93 | 3.93 |
| 449.81 | 5.89 | 5.89 |
| 297.23 | 3.38 | 3.38 |
| 357.76 | 4.69 | 4.69 |
| 397.82 | 5.61 | 5.61 |
| 270.33 | 4.09 | 4.09 |
| 280.68 | 3.76 | 3.76 |
| 331.68 | 4.03 | 4.03 |
| 326.27 | 3.99 | 3.99 |
| 401.77 | 4.14 | 4.14 |
| 373.76 | 4.70 | 4.70 |
| 331.68 | 4.03 | 4.03 |
| 344.72 | 5.20 | 5.20 |
| 383.80 | 5.22 | 5.22 |
| 327.38 | 2.89 | 2.89 |
| 336.77 | 4.97 | 4.97 |
| 311.16 | 4.58 | 4.58 |
| 355.70 | 4.51 | 4.51 |
| 365.13 | 5.29 | 5.29 |
| 311.16 | 4.58 | 4.58 |
| 299.35 | 3.66 | 3.66 |
| 298.38 | 4.57 | 4.57 |
| 370.72 | 4.00 | 4.00 |
| 284.36 | 4.26 | 4.26 |