Basic Information
ID: ALA4809445
Type: Binding
Description: Reversal of P-gp-mediated multidrug resistance in human K562/A02 cells assessed as potentiation of adriamycin-induced cytotoxicity at 5 uM by measuring adriamycin IC50 after 48 hrs by MTT assay
Format: BAO_0000219
Organism: Homo sapiens
Cell type: K562/A02
Target: P-glycoprotein 1(ALA4302)
Document: ALA4808186
Reversal of P-gp-mediated multidrug resistance in human K562/A02 cells assessed as potentiation of adriamycin-induced cytotoxicity at 5 uM by measuring adriamycin IC50 after 48 hrs by MTT assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4809445
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 454.61 | 5.09 | 5.09 |
| 493.62 | 4.59 | 4.59 |
| 646.74 | 6.37 | 6.37 |
| 469.58 | 3.64 | 3.64 |
| 605.76 | 7.13 | 7.13 |
| 599.74 | 7.07 | 7.07 |
| 524.63 | 4.40 | 4.40 |
| 629.76 | 7.07 | 7.07 |
| 589.70 | 6.66 | 6.66 |
| 537.66 | 5.31 | 5.31 |
| 500.55 | 4.37 | 4.37 |
| 513.60 | 4.59 | 4.59 |
| 541.63 | 5.14 | 5.14 |
| 539.64 | 4.71 | 4.71 |
| 484.55 | 4.66 | 4.66 |
| 553.66 | 5.01 | 5.01 |
| 615.73 | 6.77 | 6.77 |
| 523.64 | 5.00 | 5.00 |
| 514.58 | 4.67 | 4.67 |
| 498.58 | 4.97 | 4.97 |
| 613.76 | 7.37 | 7.37 |
| 502.54 | 4.80 | 4.80 |
| 524.63 | 4.40 | 4.40 |
| 617.73 | 7.21 | 7.21 |
| 615.73 | 6.77 | 6.77 |
| 529.67 | 5.06 | 5.06 |
| 600.72 | 6.46 | 6.46 |
| 600.72 | 6.46 | 6.46 |
| 539.64 | 4.71 | 4.71 |