Basic Information
ID: ALA4810615
Type: Binding
Description: Inhibition of recombinant human TDO2 expressed in Escherichia coli BL21 (DE3) assessed as reduction in N-formylkynurenine formation using L-tryptophan as substrate measured after 40 mins by methylene blue reagent based spectrophotometry
Format: BAO_0000019
Organism: Homo sapiens
Target: Tryptophan 2,3-dioxygenase(ALA2140)
Document: ALA4808224
Inhibition of recombinant human TDO2 expressed in Escherichia coli BL21 (DE3) assessed as reduction in N-formylkynurenine formation using L-tryptophan as substrate measured after 40 mins by methylene blue reagent based spectrophotometry: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4810615
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 229.22 | 1.99 | 1.99 |
| 245.29 | 3.78 | 3.78 |
| 308.34 | 1.93 | 1.93 |
| 235.25 | 2.50 | 2.50 |
| 244.30 | 4.38 | 4.38 |
| 317.40 | 3.19 | 3.19 |
| 244.30 | 4.38 | 4.38 |
| 347.42 | 2.91 | 2.91 |
| 331.42 | 3.58 | 3.58 |
| 331.42 | 3.58 | 3.58 |
| 316.29 | 4.14 | 4.14 |
| 292.30 | 2.66 | 2.66 |
| 317.40 | 3.19 | 3.19 |
| 292.30 | 2.66 | 2.66 |
| 245.29 | 3.78 | 3.78 |
| 249.28 | 2.69 | 2.69 |
| 305.39 | 3.14 | 3.14 |
| 346.44 | 2.48 | 2.48 |
| 234.26 | 3.11 | 3.11 |
| 252.25 | 3.25 | 3.25 |
| 288.35 | 3.99 | 3.99 |
| 279.26 | 3.01 | 3.01 |
| 346.44 | 2.48 | 2.48 |
| 265.32 | 2.42 | 2.42 |
| 248.29 | 3.12 | 3.12 |
| 318.38 | 3.62 | 3.62 |
| 291.31 | 2.06 | 2.06 |
| 288.35 | 3.99 | 3.99 |
| 305.39 | 3.14 | 3.14 |
| 347.42 | 2.91 | 2.91 |
| 308.34 | 1.93 | 1.93 |
| 318.38 | 3.62 | 3.62 |
| 316.29 | 4.14 | 4.14 |
| 318.38 | 3.76 | 3.76 |
| 318.38 | 3.76 | 3.76 |
| 291.31 | 2.06 | 2.06 |
| 263.30 | 2.70 | 2.70 |
| 364.43 | 2.62 | 2.62 |