Basic Information
ID: ALA4810876
Type: Binding
Description: Inhibition of biotinylated KRAS G12C mutant (unknown origin) assessed as inhibition of SOS-catalyzed nucleotide exchange preincubated for 60 mins followed by addition of human recombinant SOS protein and unlabeled GTP and measured after 60 mins by TR-FRET analysis
Format: BAO_0000357
Organism: Homo sapiens
Target: GTPase KRas(ALA2189121)
Document: ALA4808238
Inhibition of biotinylated KRAS G12C mutant (unknown origin) assessed as inhibition of SOS-catalyzed nucleotide exchange preincubated for 60 mins followed by addition of human recombinant SOS protein and unlabeled GTP and measured after 60 mins by TR-FRET analysis: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4810876
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 635.81 | 3.80 | 3.80 |
| 597.74 | 4.20 | 4.20 |
| 591.76 | 4.09 | 4.09 |
| 591.76 | 4.09 | 4.09 |
| 621.79 | 3.41 | 3.41 |
| 577.73 | 3.70 | 3.70 |
| 604.16 | 3.28 | 3.28 |
| 653.80 | 4.10 | 4.10 |
| 591.76 | 4.09 | 4.09 |
| 591.76 | 4.05 | 4.05 |
| 605.79 | 4.44 | 4.44 |