Basic Information
ID: ALA4811973
Type: Binding
Description: Inhibition Zika virus NS3B (47 to 95 residues)/NS3 (1 to 170 residues) protease expressed in Escherichia coli BL21 using 7-amino-4-methylcoumarin as substrate by fluorescence assay
Format: BAO_0000019
Organism: Zika virus
Target: Genome polyprotein(ALA4523954)
Document: ALA4811233
Inhibition Zika virus NS3B (47 to 95 residues)/NS3 (1 to 170 residues) protease expressed in Escherichia coli BL21 using 7-amino-4-methylcoumarin as substrate by fluorescence assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4811973
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 503.24 | 5.71 | 5.71 |
| 420.63 | 4.09 | 4.09 |
| 495.43 | 4.03 | 4.03 |
| 442.57 | 3.36 | 3.36 |
| 458.54 | 5.05 | 5.05 |
| 456.55 | 4.93 | 4.93 |
| 454.53 | 4.55 | 4.55 |
| 444.58 | 4.15 | 4.15 |
| 468.60 | 5.51 | 5.51 |
| 417.56 | 3.50 | 3.50 |
| 416.53 | 3.85 | 3.85 |
| 440.55 | 4.91 | 4.91 |
| 573.73 | 6.37 | 6.37 |
| 454.57 | 5.22 | 5.22 |
| 389.50 | 3.43 | 3.43 |
| 403.53 | 3.65 | 3.65 |
| 393.49 | 3.25 | 3.25 |
| 405.50 | 3.17 | 3.17 |
| 469.59 | 4.92 | 4.92 |
| 454.57 | 5.22 | 5.22 |
| 413.53 | 4.13 | 4.13 |
| 456.63 | 5.70 | 5.70 |
| 400.48 | 4.13 | 4.13 |
| 470.57 | 4.40 | 4.40 |
| 470.57 | 4.92 | 4.92 |
| 485.63 | 4.27 | 4.27 |
| 364.45 | 2.37 | 2.37 |
| 454.57 | 5.17 | 5.17 |
| 364.45 | 2.17 | 2.17 |
| 509.70 | 7.65 | 7.65 |
| 454.57 | 5.22 | 5.22 |
| 418.54 | 3.96 | 3.96 |
| 477.56 | 6.71 | 6.71 |
| 443.60 | 4.25 | 4.25 |
| 470.57 | 4.92 | 4.92 |
| 416.57 | 4.77 | 4.77 |
| 451.57 | 4.71 | 4.71 |
| 405.50 | 3.05 | 3.05 |
| 471.61 | 3.88 | 3.88 |
| 542.43 | 3.87 | 3.87 |
| 471.57 | 2.72 | 2.72 |
| 472.52 | 4.69 | 4.69 |
| 459.64 | 4.31 | 4.31 |
| 457.55 | 5.08 | 5.08 |
| 454.57 | 5.30 | 5.30 |
| 418.55 | 2.69 | 2.69 |
| 455.63 | 5.41 | 5.41 |
| 454.57 | 5.30 | 5.30 |
| 500.62 | 5.03 | 5.03 |
| 489.57 | 4.32 | 4.32 |
| 439.56 | 4.94 | 4.94 |
| 403.53 | 3.11 | 3.11 |
| 440.55 | 4.04 | 4.04 |
| 454.57 | 5.17 | 5.17 |
| 390.49 | 3.35 | 3.35 |
| 440.55 | 4.91 | 4.91 |
| 440.55 | 4.91 | 4.91 |
| 411.55 | 1.86 | 1.86 |
| 414.51 | 3.52 | 3.52 |
| 457.62 | 4.11 | 4.11 |
| 401.56 | 3.74 | 3.74 |
| 390.49 | 3.35 | 3.35 |
| 400.48 | 4.26 | 4.26 |
| 413.53 | 2.52 | 2.52 |
| 450.97 | 3.92 | 3.92 |
| 597.24 | 5.40 | 5.40 |
| 482.59 | 4.53 | 4.53 |
| 449.56 | 3.54 | 3.54 |
| 468.60 | 5.51 | 5.51 |
| 356.47 | 1.35 | 1.35 |
| 457.66 | 6.78 | 6.78 |
| 419.53 | 3.56 | 3.56 |
| 421.52 | 3.25 | 3.25 |
| 426.52 | 4.66 | 4.66 |
| 625.29 | 6.18 | 6.18 |
| 378.48 | 2.38 | 2.38 |
| 611.26 | 5.79 | 5.79 |
| 455.61 | 4.02 | 4.02 |
| 413.53 | 4.13 | 4.13 |
| 466.59 | 5.44 | 5.44 |
| 427.56 | 2.91 | 2.91 |
| 364.45 | 2.17 | 2.17 |
| 457.55 | 5.08 | 5.08 |
| 375.48 | 3.04 | 3.04 |
| 413.53 | 4.13 | 4.13 |
| 487.60 | 3.46 | 3.46 |
| 445.57 | 3.28 | 3.28 |
| 457.62 | 4.64 | 4.64 |
| 487.60 | 3.12 | 3.12 |
| 439.56 | 6.49 | 6.49 |
| 465.56 | 4.78 | 4.78 |
| 444.58 | 4.15 | 4.15 |
| 438.58 | 5.55 | 5.55 |
| 414.51 | 3.52 | 3.52 |
| 431.58 | 3.72 | 3.72 |
| 418.55 | 2.01 | 2.01 |
| 441.54 | 3.23 | 3.23 |
| 433.51 | 6.11 | 6.11 |
| 455.56 | 3.81 | 3.81 |
| 365.44 | 1.56 | 1.56 |