Basic Information
ID: ALA4812388
Type: Binding
Description: Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaphorase/resazurin-coupled system
Format: BAO_0000357
Organism: Homo sapiens
Target: Isocitrate dehydrogenase [NADP] cytoplasmic(ALA2007625)
Document: ALA4811250
Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 5 mins by diaphorase/resazurin-coupled system: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4812388
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 521.04 | 6.45 | 6.45 |
| 489.04 | 7.00 | 7.00 |
| 582.97 | 4.32 | 4.32 |
| 593.58 | 6.97 | 6.97 |
| 613.23 | 7.41 | 7.41 |
| 492.04 | 6.07 | 6.07 |
| 505.04 | 6.75 | 6.75 |
| 548.11 | 6.19 | 6.19 |
| 631.24 | 6.42 | 6.42 |
| 469.54 | 4.86 | 4.86 |
| 505.00 | 6.13 | 6.13 |
| 534.13 | 7.10 | 7.10 |
| 587.19 | 6.40 | 6.40 |
| 519.07 | 7.22 | 7.22 |
| 507.06 | 6.81 | 6.81 |
| 503.07 | 7.31 | 7.31 |
| 521.04 | 6.45 | 6.45 |
| 469.54 | 5.07 | 5.07 |
| 521.04 | 6.45 | 6.45 |
| 479.00 | 6.41 | 6.41 |
| 505.04 | 6.89 | 6.89 |
| 589.16 | 6.32 | 6.32 |
| 601.22 | 7.26 | 7.26 |
| 505.04 | 6.84 | 6.84 |
| 549.09 | 7.23 | 7.23 |
| 629.15 | 6.95 | 6.95 |
| 549.14 | 6.05 | 6.05 |
| 616.23 | 5.60 | 5.60 |
| 506.07 | 6.42 | 6.42 |
| 479.58 | 6.34 | 6.34 |
| 575.18 | 6.58 | 6.58 |
| 561.15 | 6.10 | 6.10 |
| 655.19 | 7.81 | 7.81 |
| 514.02 | 7.00 | 7.00 |
| 615.24 | 7.65 | 7.65 |
| 531.08 | 5.75 | 5.75 |
| 613.23 | 7.41 | 7.41 |
| 549.09 | 7.23 | 7.23 |
| 547.12 | 5.76 | 5.76 |
| 617.22 | 6.24 | 6.24 |
| 536.10 | 6.09 | 6.09 |
| 535.11 | 5.66 | 5.66 |
| 486.59 | 5.80 | 5.80 |
| 587.19 | 6.87 | 6.87 |
| 489.04 | 6.80 | 6.80 |
| 493.97 | 4.58 | 4.58 |
| 438.94 | 5.61 | 5.61 |
| 630.21 | 5.73 | 5.73 |
| 522.07 | 5.44 | 5.44 |
| 535.02 | 6.14 | 6.14 |
| 492.00 | 5.84 | 5.84 |
| 503.99 | 5.72 | 5.72 |
| 467.03 | 6.95 | 6.95 |
| 535.07 | 4.93 | 4.93 |
| 528.98 | 7.46 | 7.46 |
| 629.27 | 8.04 | 8.04 |
| 560.16 | 7.78 | 7.78 |
| 601.22 | 7.26 | 7.26 |
| 617.21 | 6.03 | 6.03 |
| 589.21 | 6.65 | 6.65 |
| 521.04 | 6.45 | 6.45 |
| 573.16 | 6.62 | 6.62 |
| 536.05 | 5.53 | 5.53 |
| 568.14 | 7.64 | 7.64 |
| 517.09 | 7.56 | 7.56 |
| 575.18 | 6.40 | 6.40 |
| 424.91 | 5.30 | 5.30 |
| 573.16 | 6.62 | 6.62 |
| 535.02 | 6.14 | 6.14 |
| 569.13 | 8.25 | 8.25 |
| 525.05 | 6.28 | 6.28 |
| 599.20 | 6.87 | 6.87 |
| 612.20 | 6.77 | 6.77 |
| 544.98 | 7.34 | 7.34 |
| 613.23 | 7.41 | 7.41 |
| 521.09 | 5.40 | 5.40 |
| 492.00 | 5.84 | 5.84 |
| 520.10 | 6.85 | 6.85 |
| 493.03 | 6.50 | 6.50 |
| 535.02 | 6.14 | 6.14 |
| 495.43 | 7.09 | 7.09 |
| 601.17 | 6.40 | 6.40 |
| 495.00 | 5.94 | 5.94 |
| 491.01 | 6.45 | 6.45 |
| 591.18 | 5.64 | 5.64 |
| 492.03 | 6.37 | 6.37 |
| 493.97 | 4.58 | 4.58 |
| 593.58 | 6.97 | 6.97 |
| 535.02 | 6.14 | 6.14 |
| 559.13 | 6.31 | 6.31 |
| 631.20 | 6.33 | 6.33 |