Basic Information
ID: ALA4812389
Type: Binding
Description: Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate at 38 uM incubated for 5 mins by diaphorase/resazurin-coupled system relative to control
Format: BAO_0000357
Organism: Homo sapiens
Target: Isocitrate dehydrogenase [NADP] cytoplasmic(ALA2007625)
Document: ALA4811250
Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate at 38 uM incubated for 5 mins by diaphorase/resazurin-coupled system relative to control: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4812389
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 521.04 | 6.45 | 6.45 |
| 489.04 | 7.00 | 7.00 |
| 492.04 | 6.07 | 6.07 |
| 505.04 | 6.75 | 6.75 |
| 537.08 | 8.10 | 8.10 |
| 548.11 | 6.19 | 6.19 |
| 476.00 | 6.02 | 6.02 |
| 631.24 | 6.42 | 6.42 |
| 469.54 | 4.86 | 4.86 |
| 546.14 | 7.34 | 7.34 |
| 505.00 | 6.13 | 6.13 |
| 469.54 | 4.86 | 4.86 |
| 587.19 | 6.40 | 6.40 |
| 519.07 | 7.22 | 7.22 |
| 507.06 | 6.81 | 6.81 |
| 503.07 | 7.31 | 7.31 |
| 503.07 | 7.56 | 7.56 |
| 460.99 | 6.44 | 6.44 |
| 469.54 | 5.07 | 5.07 |
| 479.00 | 6.41 | 6.41 |
| 505.04 | 6.89 | 6.89 |
| 505.04 | 6.84 | 6.84 |
| 549.09 | 7.23 | 7.23 |
| 629.15 | 6.95 | 6.95 |
| 549.14 | 6.05 | 6.05 |
| 616.23 | 5.60 | 5.60 |
| 534.13 | 7.24 | 7.24 |
| 506.07 | 6.42 | 6.42 |
| 575.18 | 6.58 | 6.58 |
| 561.15 | 6.10 | 6.10 |
| 553.08 | 8.23 | 8.23 |
| 490.97 | 6.16 | 6.16 |
| 478.98 | 6.58 | 6.58 |
| 490.03 | 6.48 | 6.48 |
| 554.12 | 7.97 | 7.97 |
| 503.99 | 5.52 | 5.52 |
| 492.98 | 5.82 | 5.82 |
| 549.09 | 7.23 | 7.23 |
| 547.12 | 5.76 | 5.76 |
| 536.10 | 6.09 | 6.09 |
| 535.11 | 5.66 | 5.66 |
| 486.59 | 5.80 | 5.80 |
| 469.54 | 4.86 | 4.86 |
| 587.19 | 6.87 | 6.87 |
| 469.54 | 5.07 | 5.07 |
| 493.97 | 4.58 | 4.58 |
| 522.07 | 5.44 | 5.44 |
| 492.00 | 5.84 | 5.84 |
| 503.99 | 5.72 | 5.72 |
| 504.06 | 6.50 | 6.50 |
| 535.07 | 4.93 | 4.93 |
| 528.98 | 7.46 | 7.46 |
| 426.97 | 6.03 | 6.03 |
| 515.01 | 6.39 | 6.39 |
| 617.21 | 6.03 | 6.03 |
| 475.01 | 6.74 | 6.74 |
| 589.21 | 6.65 | 6.65 |
| 495.00 | 5.94 | 5.94 |
| 505.04 | 6.50 | 6.50 |
| 521.04 | 6.45 | 6.45 |
| 536.05 | 5.53 | 5.53 |
| 517.09 | 7.56 | 7.56 |
| 575.18 | 6.40 | 6.40 |
| 535.02 | 6.14 | 6.14 |
| 494.98 | 4.59 | 4.59 |
| 525.05 | 6.28 | 6.28 |
| 544.98 | 7.34 | 7.34 |
| 461.97 | 5.83 | 5.83 |
| 521.09 | 5.40 | 5.40 |
| 520.10 | 6.85 | 6.85 |
| 521.04 | 6.45 | 6.45 |
| 535.02 | 6.14 | 6.14 |
| 495.43 | 7.09 | 7.09 |
| 491.01 | 6.45 | 6.45 |
| 567.11 | 8.02 | 8.02 |
| 476.99 | 6.14 | 6.14 |
| 478.96 | 5.43 | 5.43 |
| 591.18 | 5.64 | 5.64 |
| 492.03 | 6.37 | 6.37 |
| 493.97 | 4.58 | 4.58 |
| 469.54 | 4.86 | 4.86 |
| 535.02 | 6.14 | 6.14 |