Basic Information
ID: ALA4813265
Type: Binding
Description: Inhibition of NLRP3 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated with compound for 1 hr followed by nigericin stimulation for 1 hr by ELISA
Format: BAO_0000221
Organism: Mus musculus
Cell type: J774.A1
Target: NACHT, LRR and PYD domains-containing protein 3(ALA3779755)
Document: ALA4811287
Inhibition of NLRP3 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated with compound for 1 hr followed by nigericin stimulation for 1 hr by ELISA: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4813265
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 556.77 | 7.05 | 7.05 |
| 520.71 | 7.64 | 7.64 |
| 584.82 | 7.36 | 7.36 |
| 613.87 | 6.52 | 6.52 |
| 612.81 | 8.94 | 8.94 |
| 568.78 | 7.56 | 7.56 |
| 563.78 | 8.21 | 8.21 |
| 599.84 | 7.33 | 7.33 |
| 570.80 | 7.44 | 7.44 |
| 632.87 | 8.79 | 8.79 |
| 589.82 | 8.74 | 8.74 |
| 624.89 | 8.75 | 8.75 |
| 463.66 | 7.68 | 7.68 |
| 585.81 | 6.90 | 6.90 |
| 572.77 | 6.52 | 6.52 |
| 571.78 | 6.55 | 6.55 |
| 619.83 | 7.87 | 7.87 |
| 648.87 | 8.49 | 8.49 |
| 626.90 | 8.49 | 8.49 |
| 562.80 | 8.66 | 8.66 |
| 603.85 | 9.13 | 9.13 |
| 627.83 | 9.33 | 9.33 |
| 532.73 | 7.80 | 7.80 |
| 542.74 | 6.32 | 6.32 |
| 686.84 | 9.50 | 9.50 |
| 618.84 | 8.48 | 8.48 |
| 556.77 | 6.59 | 6.59 |
| 582.81 | 7.58 | 7.58 |
| 570.80 | 6.93 | 6.93 |
| 632.25 | 9.97 | 9.97 |
| 563.78 | 8.21 | 8.21 |
| 622.81 | 9.19 | 9.19 |
| 548.77 | 8.27 | 8.27 |
| 636.83 | 8.62 | 8.62 |
| 611.83 | 9.63 | 9.63 |
| 478.68 | 7.26 | 7.26 |
| 582.79 | 8.93 | 8.93 |
| 562.80 | 8.81 | 8.81 |