Basic Information
ID: ALA4813813
Type: Binding
Description: Inhibition of acid-mediated aggregation of TTR V30M mutant (unknown origin) expressed in Escherichia coli pretreated for 30 mins at pH 7 followed by protein dilution in acetate buffer and further incubated for 96 hrs at pH 4.6 by thioflavin-T fluorescence assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4813813
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 240.21 | 1.87 | 1.87 |
| 240.21 | 2.64 | 2.64 |
| 272.21 | 1.28 | 1.28 |
| 270.24 | 1.89 | 1.89 |
| 284.27 | 2.19 | 2.19 |
| 254.24 | 2.18 | 2.18 |
| 284.22 | 1.57 | 1.57 |
| 368.30 | 2.01 | 2.01 |
| 270.24 | 1.37 | 1.37 |
| 250.20 | 3.04 | 3.04 |
| 240.21 | 1.87 | 1.87 |
| 240.21 | 1.87 | 1.87 |
| 240.21 | 1.87 | 1.87 |
| 256.21 | 1.58 | 1.58 |
| 527.53 | 1.03 | 1.03 |
| 396.44 | 4.79 | 4.79 |
| 252.22 | 2.16 | 2.16 |
| 210.23 | 3.25 | 3.25 |
| 308.12 | 4.50 | 4.50 |
| 268.22 | 1.87 | 1.87 |
| 296.28 | 2.56 | 2.56 |
| 286.67 | 2.81 | 2.81 |
| 266.25 | 2.47 | 2.47 |
| 254.24 | 2.95 | 2.95 |
| 274.66 | 3.30 | 3.30 |
| 242.23 | 2.82 | 2.82 |
| 309.10 | 3.95 | 3.95 |
| 274.66 | 3.30 | 3.30 |
| 274.66 | 3.30 | 3.30 |
| 310.26 | 2.09 | 2.09 |
| 296.23 | 1.86 | 1.86 |
| 240.21 | 2.64 | 2.64 |
| 210.23 | 3.25 | 3.25 |
| 266.25 | 2.47 | 2.47 |
| 256.21 | 1.58 | 1.58 |
| 274.66 | 3.30 | 3.30 |
| 274.66 | 3.30 | 3.30 |
| 274.66 | 3.30 | 3.30 |
| 357.28 | 0.70 | 0.70 |
| 270.21 | 2.30 | 2.30 |
| 372.29 | 0.28 | 0.28 |
| 274.66 | 3.30 | 3.30 |
| 274.66 | 3.30 | 3.30 |
| 390.00 | 4.77 | 4.77 |
| 274.66 | 3.30 | 3.30 |