Basic Information
ID: ALA4817529
Type: Binding
Description: Inhibition of ASM in dog MDCK cells co-expressing recombinant full length mGFP-tagged KRAS G12V mutant and mCherry-CAAX assessed as reduction in plasma membrane localization of KRAS mutant incubated for 48 hrs by confocal microscopic analysis relative to control
Organism: Canis lupus familiaris
Cell type: MDCK
Subcellular Fraction: Plasma Membrane
Activity Charts
Bioactivity
Activity Types for Assay ALA4817529
Emax
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 393.58 | 4.02 | 4.02 |
| 371.52 | 6.21 | 6.21 |
| 455.65 | 5.10 | 5.10 |
| 535.73 | 9.32 | 9.32 |
| 389.51 | 6.16 | 6.16 |
| 484.64 | 5.34 | 5.34 |
| 469.67 | 5.44 | 5.44 |
| 483.70 | 5.83 | 5.83 |
| 383.54 | 6.38 | 6.38 |
| 474.09 | 6.08 | 6.08 |
| 469.67 | 5.44 | 5.44 |
| 440.63 | 6.29 | 6.29 |
| 454.66 | 6.68 | 6.68 |
| 497.73 | 6.22 | 6.22 |
| 469.63 | 4.62 | 4.62 |
| 457.64 | 5.57 | 5.57 |
| 456.63 | 5.52 | 5.52 |
| 469.67 | 5.44 | 5.44 |
| 317.48 | 2.49 | 2.49 |
| 414.59 | 5.75 | 5.75 |
| 426.60 | 5.90 | 5.90 |
| 469.67 | 5.44 | 5.44 |
| 483.66 | 4.96 | 4.96 |
| 439.65 | 5.43 | 5.43 |
| 357.50 | 5.82 | 5.82 |
| 474.09 | 6.08 | 6.08 |
| 483.66 | 4.96 | 4.96 |
| 387.52 | 5.18 | 5.18 |
| 442.65 | 6.53 | 6.53 |