Basic Information
ID: ALA4817532
Type: Binding
Description: Inhibition of ASM in dog MDCK cells co-expressing recombinant full length mGFP-tagged KRAS G12V mutant and mCherry-CAAX assessed as reduction in plasma membrane localization of KRAS mutant at 1 uM incubated for 48 hrs followed by incubation with recombinant ASM in continued presence of compound for 60 mins by confocal microscopic analysis
Organism: Canis lupus familiaris
Cell type: MDCK
Subcellular Fraction: Plasma Membrane
Activity Charts
Bioactivity
Activity Types for Assay ALA4817532
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 483.70 | 5.83 | 5.83 |
| 469.67 | 5.44 | 5.44 |
| 440.63 | 6.29 | 6.29 |