Basic Information
ID: ALA4817557
Type: Functional
Description: In vivo inhibition of KRAS signaling in nu/nu mouse xenografted with human MIA PaCa-2 cells harboring KRAS mutation assessed as decrease in ERK phosphorylation in tumor at 1 to 5 mg/kg, ip administered once daily for 5 days with 2 days break by immunohistochemistry
Organism: Mus musculus
Activity Charts
Bioactivity
Activity Types for Assay ALA4817557
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 315.46 | 5.56 | 5.56 |
| 483.70 | 5.83 | 5.83 |
| 440.63 | 6.29 | 6.29 |