Basic Information
ID: ALA4817562
Type: Binding
Description: Inhibition of ASM in dog MDCK cells co-expressing recombinant full length mGFP-tagged KRAS G12V mutant and mCherry-CAAX assessed as reduction in plasma membrane localization of KRAS mutant at 10 uM incubated for 48 hrs followed by incubation with recombinant ASM in continued presence of compound for 60 mins by confocal microscopic analysis
Format: BAO_0000249
Organism: Canis lupus familiaris
Cell type: MDCK
Subcellular Fraction: Plasma Membrane
Target: Unchecked(ALA612545)
Document: ALA4814013
Inhibition of ASM in dog MDCK cells co-expressing recombinant full length mGFP-tagged KRAS G12V mutant and mCherry-CAAX assessed as reduction in plasma membrane localization of KRAS mutant at 10 uM incubated for 48 hrs followed by incubation with recombinant ASM in continued presence of compound for 60 mins by confocal microscopic analysis: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4817562
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 315.46 | 5.56 | 5.56 |