Basic Information
ID: ALA4824988
Type: Binding
Description: Inhibition of human PDHK4 co-complexed with porcine PDH using sodium pyruvate, coenzymeA and NAD as substrate at IC50 preincubated with enzyme complex for 45 mins followed by ATP addition and then later incubated with substrate for 90 mins by absorption spectrophotometric assay relative to control
Format: BAO_0000357
Organism: Homo sapiens
Target: Pyruvate dehydrogenase kinase isoform 4(ALA4141)
Document: ALA4823293
Inhibition of human PDHK4 co-complexed with porcine PDH using sodium pyruvate, coenzymeA and NAD as substrate at IC50 preincubated with enzyme complex for 45 mins followed by ATP addition and then later incubated with substrate for 90 mins by absorption spectrophotometric assay relative to control: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4824988
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 161.20 | 1.92 | 1.92 |
| 176.22 | 1.50 | 1.50 |
| 200.24 | 2.09 | 2.09 |
| 189.26 | 2.53 | 2.53 |
| 189.26 | 2.48 | 2.48 |
| 303.55 | 2.04 | 2.04 |
| 223.71 | 3.18 | 3.18 |
| 238.68 | 1.59 | 1.59 |
| 208.26 | 3.59 | 3.59 |