Basic Information
ID: ALA4825223
Type: Binding
Description: Inhibition of C-KIT V654A/560-576 deletion mutant in human GIST-430/654 cells assessed as reduction in c-Kit autophosphorylation at Tyr307 residue incubated for 45 mins by Luminex bead based assay
Format: BAO_0000219
Organism: Homo sapiens
Cell type: GIST-430/654
Target: Unchecked(ALA612545)
Document: ALA4823309
Inhibition of C-KIT V654A/560-576 deletion mutant in human GIST-430/654 cells assessed as reduction in c-Kit autophosphorylation at Tyr307 residue incubated for 45 mins by Luminex bead based assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4825223
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 509.62 | 4.06 | 4.06 |
| 411.47 | 3.81 | 3.81 |
| 553.67 | 3.94 | 3.94 |
| 465.57 | 3.21 | 3.21 |
| 412.46 | 3.21 | 3.21 |
| 442.48 | 3.74 | 3.74 |
| 523.60 | 2.91 | 2.91 |
| 480.58 | 3.74 | 3.74 |
| 550.67 | 4.44 | 4.44 |
| 467.53 | 3.97 | 3.97 |
| 367.42 | 3.59 | 3.59 |
| 549.68 | 3.36 | 3.36 |