Basic Information
ID: ALA4825224
Type: Binding
Description: Inhibition of biotinylated KRAS G12C/C51S/C80L/C118S mutant (unknown origin) pretreated for 60 mins followed by recombinant SOS addition by SOS-catalyzed nucleotide exchange-based TR-FRET analysis
Format: BAO_0000357
Organism: Homo sapiens
Target: GTPase KRas(ALA2189121)
Document: ALA4823310
Inhibition of biotinylated KRAS G12C/C51S/C80L/C118S mutant (unknown origin) pretreated for 60 mins followed by recombinant SOS addition by SOS-catalyzed nucleotide exchange-based TR-FRET analysis: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4825224
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 636.10 | 5.23 | 5.23 |
| 617.12 | 5.70 | 5.70 |
| 641.11 | 5.28 | 5.28 |
| 653.11 | 5.94 | 5.94 |
| 632.69 | 5.88 | 5.88 |
| 600.67 | 5.18 | 5.18 |
| 586.64 | 4.79 | 4.79 |
| 600.67 | 5.18 | 5.18 |
| 614.70 | 5.57 | 5.57 |
| 637.09 | 5.28 | 5.28 |
| 603.10 | 5.31 | 5.31 |
| 669.10 | 5.78 | 5.78 |