Basic Information
ID: ALA4828378
Type: Binding
Description: Inhibition of CYP2C19 in human liver microsomes assessed as remaining activity at 1 to 10 uM using (S)-mephenytoin as substrate preincubated for 5 mins followed by addition of NADPH generation system for 15 mins by LC-MS/MS analysis
Format: BAO_0000251
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: Microsomes
Target: Cytochrome P450 2C19(ALA3622)
Document: ALA4825758
Inhibition of CYP2C19 in human liver microsomes assessed as remaining activity at 1 to 10 uM using (S)-mephenytoin as substrate preincubated for 5 mins followed by addition of NADPH generation system for 15 mins by LC-MS/MS analysis: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4828378
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 454.61 | 5.09 | 5.09 |
| 531.44 | 4.21 | 4.21 |
| 276.77 | 2.53 | 2.53 |