Basic Information
ID: ALA4828599
Type: Binding
Description: Inhibition of GDP-bound KRAS G12C mutant (1 to 169 residues) (unknown origin) assessed as inhibition of SOS-mediated nucleotide exchange pretreated with KRAS for 5 mins followed by incubation with SOS (564 to 1049 residues) and GTP for 30 mins and later incubated with GST-tagged cRAF (1 to 149 residues) for 10 mins by AlphaLISA assay
Format: BAO_0000357
Organism: Homo sapiens
Target: GTPase KRas(ALA2189121)
Document: ALA4825768
Inhibition of GDP-bound KRAS G12C mutant (1 to 169 residues) (unknown origin) assessed as inhibition of SOS-mediated nucleotide exchange pretreated with KRAS for 5 mins followed by incubation with SOS (564 to 1049 residues) and GTP for 30 mins and later incubated with GST-tagged cRAF (1 to 149 residues) for 10 mins by AlphaLISA assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4828599
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 577.06 | 4.50 | 4.50 |
| 549.01 | 3.77 | 3.77 |
| 606.10 | 4.47 | 4.47 |
| 607.09 | 4.60 | 4.60 |
| 563.03 | 4.30 | 4.30 |
| 649.12 | 4.43 | 4.43 |
| 619.10 | 4.83 | 4.83 |
| 563.03 | 4.11 | 4.11 |
| 607.09 | 3.86 | 3.86 |
| 591.09 | 4.89 | 4.89 |
| 674.22 | 5.36 | 5.36 |