Basic Information
ID: ALA4828801
Type: Binding
Description: Inhibition of human recombinant CDK12/CyclinK assessed as reduction in substrate phosphorylation using His-c-Myc as substrate preincubated with enzyme for 5 mins followed by substrate addition for 15 mins in presence of [gamma 32P-ATP] by radioactive kinase assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4828801
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 558.09 | 5.05 | 5.05 |
| 531.06 | 4.81 | 4.81 |
| 563.08 | 6.28 | 6.28 |
| 545.09 | 6.14 | 6.14 |
| 501.98 | 4.51 | 4.51 |
| 559.07 | 4.45 | 4.45 |
| 563.71 | 5.28 | 5.28 |
| 505.00 | 6.01 | 6.01 |
| 519.02 | 6.32 | 6.32 |
| 591.64 | 5.42 | 5.42 |
| 501.03 | 6.18 | 6.18 |
| 544.06 | 4.66 | 4.66 |
| 545.09 | 6.14 | 6.14 |
| 602.54 | 5.16 | 5.16 |
| 502.02 | 6.60 | 6.60 |
| 487.01 | 5.87 | 5.87 |
| 488.00 | 5.27 | 5.27 |
| 530.08 | 5.42 | 5.42 |
| 572.11 | 5.44 | 5.44 |
| 531.06 | 6.19 | 6.19 |