Basic Information
ID: ALA4833231
Type: Binding
Description: Inhibition of NLRP3 inflammasome activation in LPS-stimulated mouse J774A.1 cells assessed as inhibition of cell pyrolysis at 10 uM incubated for 1 hr followed by ATP addition and measured after 30 mins by Hoechst 33342/propidium iodide staining based high content screening method relative to control
Organism: Mus musculus
Cell type: J774.A1
Activity Charts
Bioactivity
Activity Types for Assay ALA4833231
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 364.44 | 0.38 | 0.38 |
| 193.16 | 1.66 | 1.66 |
| 475.50 | 4.21 | 4.21 |
| 402.83 | 4.30 | 4.30 |
| 482.53 | 4.04 | 4.04 |
| 426.43 | 3.62 | 3.62 |
| 394.43 | 4.47 | 4.47 |
| 490.51 | 5.15 | 5.15 |
| 426.47 | 5.47 | 5.47 |
| 440.50 | 4.42 | 4.42 |
| 326.35 | 3.70 | 3.70 |
| 314.38 | 3.90 | 3.90 |
| 395.46 | 5.47 | 5.47 |
| 408.45 | 4.86 | 4.86 |
| 478.48 | 5.28 | 5.28 |
| 414.42 | 6.47 | 6.47 |
| 494.93 | 5.79 | 5.79 |
| 381.43 | 3.68 | 3.68 |
| 422.48 | 5.25 | 5.25 |
| 424.50 | 5.50 | 5.50 |
| 328.41 | 4.29 | 4.29 |
| 324.42 | 5.22 | 5.22 |
| 520.54 | 5.16 | 5.16 |
| 470.53 | 4.35 | 4.35 |
| 424.50 | 5.50 | 5.50 |
| 382.42 | 4.47 | 4.47 |
| 485.46 | 6.72 | 6.72 |
| 380.40 | 4.25 | 4.25 |
| 474.51 | 4.82 | 4.82 |
| 396.44 | 4.86 | 4.86 |
| 398.42 | 3.71 | 3.71 |
| 399.44 | 4.54 | 4.54 |
| 327.34 | 3.83 | 3.83 |
| 385.42 | 4.15 | 4.15 |
| 488.54 | 5.13 | 5.13 |
| 539.38 | 5.90 | 5.90 |
| 504.54 | 4.83 | 4.83 |
| 508.96 | 5.47 | 5.47 |
| 436.51 | 5.64 | 5.64 |
| 416.86 | 4.69 | 4.69 |
| 394.43 | 4.64 | 4.64 |
| 567.64 | 5.02 | 5.02 |
| 466.53 | 4.95 | 4.95 |
| 396.44 | 4.72 | 4.72 |
| 410.47 | 5.25 | 5.25 |
| 553.41 | 5.58 | 5.58 |
| 488.54 | 4.86 | 4.86 |
| 403.48 | 4.57 | 4.57 |
| 368.39 | 4.08 | 4.08 |
| 499.52 | 4.69 | 4.69 |