Basic Information
ID: ALA4834546
Type: Binding
Description: Inhibition of human PXR expressed in HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter at 10 uM incubated for 24 hrs in presence of 5 uM rifampicin by luciferase reporter assay relative to control
Organism: Homo sapiens
Cell type: HepG2
Activity Charts
Bioactivity
Activity Types for Assay ALA4834546
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 410.50 | 3.59 | 3.59 |
| 415.52 | 3.21 | 3.21 |
| 426.50 | 3.29 | 3.29 |
| 453.49 | 4.73 | 4.73 |
| 405.91 | 4.06 | 4.06 |
| 416.50 | 3.00 | 3.00 |
| 413.54 | 4.28 | 4.28 |
| 429.54 | 3.98 | 3.98 |
| 424.53 | 3.89 | 3.89 |
| 473.60 | 4.48 | 4.48 |
| 477.97 | 4.15 | 4.15 |
| 401.49 | 3.41 | 3.41 |
| 464.39 | 4.48 | 4.48 |
| 457.55 | 3.81 | 3.81 |
| 385.49 | 3.71 | 3.71 |
| 431.51 | 3.31 | 3.31 |
| 441.55 | 4.23 | 4.23 |
| 433.96 | 4.62 | 4.62 |
| 415.52 | 3.72 | 3.72 |
| 433.96 | 4.68 | 4.68 |
| 417.51 | 4.16 | 4.16 |
| 403.48 | 3.85 | 3.85 |
| 433.51 | 3.86 | 3.86 |
| 498.83 | 5.13 | 5.13 |
| 433.96 | 4.68 | 4.68 |
| 420.92 | 3.64 | 3.64 |
| 385.49 | 3.71 | 3.71 |
| 444.94 | 4.24 | 4.24 |
| 400.50 | 3.30 | 3.30 |
| 399.52 | 4.02 | 4.02 |
| 454.38 | 5.02 | 5.02 |
| 429.54 | 4.03 | 4.03 |
| 413.54 | 4.33 | 4.33 |
| 419.93 | 4.37 | 4.37 |