Basic Information
ID: ALA4834664
Type: ADME
Description: Reversible inhibition of CYP2C9 in human liver microsomes using midazolam as substrate incubated for 10 mins in presence of NADPH by LC-MS analysis
Format: BAO_0000251
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: Microsomes
Target: Cytochrome P450 2C9(ALA3397)
Document: ALA4834397
Reversible inhibition of CYP2C9 in human liver microsomes using midazolam as substrate incubated for 10 mins in presence of NADPH by LC-MS analysis: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4834664
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 357.80 | 2.92 | 2.92 |
| 295.35 | 2.40 | 2.40 |
| 373.80 | 2.46 | 2.46 |
| 329.79 | 3.13 | 3.13 |
| 373.80 | 2.59 | 2.59 |
| 373.80 | 2.59 | 2.59 |
| 329.79 | 3.31 | 3.31 |
| 329.79 | 3.13 | 3.13 |
| 358.79 | 3.65 | 3.65 |
| 359.77 | 2.20 | 2.20 |
| 344.76 | 3.26 | 3.26 |
| 315.76 | 2.74 | 2.74 |