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ID: ALA4835452
Type: Binding
Description: Inhibition of PI3Kdelta in human Ramos cells assessed as reduction in anti-IgM-antibody-induced phosphorylation of AKT at Ser473 residue preincubated for 20 mins followed by anti-IgM antibody stimulation and measured after 30 mins by alphascreen assay
Organism: Homo sapiens
Cell type: Ramos
Bioactivity
Activity Types for Assay ALA4835452
IC50
Parent Molecular Weight | ALogP | Polar Surface Area |
---|---|---|
382.47 | 1.98 | 1.98 |
436.52 | 2.05 | 2.05 |
422.54 | 2.85 | 2.85 |
445.45 | 3.35 | 3.35 |
365.44 | 2.16 | 2.16 |
476.46 | 2.94 | 2.94 |
366.43 | 1.55 | 1.55 |
437.50 | 2.02 | 2.02 |
396.50 | 2.46 | 2.46 |
410.53 | 2.85 | 2.85 |
413.55 | 3.21 | 3.21 |
432.48 | 2.71 | 2.71 |
392.47 | 2.03 | 2.03 |
436.52 | 2.05 | 2.05 |
473.42 | 3.21 | 3.21 |
442.47 | 2.67 | 2.67 |
490.49 | 3.33 | 3.33 |
443.46 | 2.64 | 2.64 |
399.43 | 2.00 | 2.00 |
368.45 | 1.97 | 1.97 |
394.48 | 2.42 | 2.42 |
450.47 | 3.00 | 3.00 |
419.41 | 2.87 | 2.87 |
380.46 | 2.03 | 2.03 |
393.45 | 2.00 | 2.00 |
491.47 | 2.83 | 2.83 |
395.47 | 2.17 | 2.17 |
438.49 | 1.52 | 1.52 |
419.45 | 1.93 | 1.93 |
437.50 | 2.02 | 2.02 |
408.51 | 2.78 | 2.78 |
381.44 | 1.86 | 1.86 |
420.43 | 1.89 | 1.89 |
407.48 | 2.39 | 2.39 |
446.43 | 3.32 | 3.32 |
381.48 | 2.58 | 2.58 |
437.51 | 1.55 | 1.55 |
406.49 | 2.42 | 2.42 |