Basic Information
ID: ALA4835717
Type: Binding
Description: Molecular glue activity at CRBN/MDM2/p53 in human RS4-11 cells assessed as induction of p53 degradation at 100 nM pretreated with CRBN ligand, lenalidomide for 1 hr followed by incubation with compound for 6 hrs by western blot analysis
Format: BAO_0000219
Organism: Homo sapiens
Cell type: RS4-11
Target: Cereblon/Tumour suppressor p53/oncoprotein Mdm2(ALA4879538)
Document: ALA4834427
Molecular glue activity at CRBN/MDM2/p53 in human RS4-11 cells assessed as induction of p53 degradation at 100 nM pretreated with CRBN ligand, lenalidomide for 1 hr followed by incubation with compound for 6 hrs by western blot analysis: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4835717
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 846.30 | 6.77 | 6.77 |