Basic Information
ID: ALA4836402
Type: Binding
Description: Inhibition of human liver mitochondrial KMO assessed as reduction in 3-HK metabolite formation using L-kynurenine as substrate preincubated for 5 mins followed by substate addition and measured after 30 mins by LC-MS/MS analysis
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: Mitochondria
Activity Charts
Bioactivity
Activity Types for Assay ALA4836402
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 421.46 | 3.54 | 3.54 |
| 408.53 | 4.24 | 4.24 |
| 408.50 | 3.05 | 3.05 |
| 426.52 | 4.38 | 4.38 |
| 434.54 | 3.44 | 3.44 |
| 364.45 | 3.03 | 3.03 |
| 426.52 | 4.38 | 4.38 |
| 426.52 | 4.38 | 4.38 |
| 434.54 | 3.44 | 3.44 |
| 418.42 | 3.58 | 3.58 |
| 426.52 | 4.38 | 4.38 |
| 394.47 | 2.66 | 2.66 |
| 418.54 | 4.20 | 4.20 |
| 434.54 | 3.58 | 3.58 |
| 420.51 | 3.19 | 3.19 |
| 378.47 | 3.42 | 3.42 |
| 392.50 | 3.67 | 3.67 |